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Literature summary for 6.2.1.4 extracted from

  • Luis, P.B.; Ruiter, J.; Ijlst, L.; de Almeida, I.T.; Duran, M.; Wanders, R.J.; Silva, M.F.
    Valproyl-CoA inhibits the activity of ATP- and GTP-dependent succinate CoA ligases (2014), J. Inherit. Metab. Dis., 37, 353-357.
    View publication on PubMed
Search for more literature for 6.2.1.4

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by valproic acid Homo sapiens
valproyl-CoA 25-50% inhibition at 1 mM Homo sapiens
ZnCl2 complete inhibition at 1mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.63
-
 GTP at pH 8.0 and 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GDP + phosphate + succinyl-CoA Homo sapiens
-
 GTP + succinate + CoA
-
 r
GTP + succinate + CoA Homo sapiens
-
 GDP + phosphate + succinyl-CoA
-
 r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP + phosphate + succinyl-CoA
-
 Homo sapiens GTP + succinate + CoA
-
 r
GTP + succinate + CoA
-
 Homo sapiens GDP + phosphate + succinyl-CoA
-
 r

Synonyms

Synonyms Comment Organism
G-SUCL
-
 Homo sapiens
GTP-dependent succinate:CoA ligase
-
 Homo sapiens
GTP-specific succinate:CoA ligase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
GTP
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism key role of the enzyme in the Krebs cycle Homo sapiens