BRENDA - Enzyme Database show
show all sequences of 6.2.1.4

Novel reaction of succinyl coenzyme A (succinyl-CoA) synthetase: activation of 3-sulfinopropionate to 3-Sulfinopropionyl-CoA in Advenella mimigardefordensis strain DPN7T during degradation of 3,3-dithiodipropionic acid

Schuermann, M.; Wuebbeler, J.H.; Grote, J.; Steinbuechel, A.; J. Bacteriol. 193, 3078-3089 (2011)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene sucCD, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)/pLysS; gene sucCD, expression in Escherichia coli strain BL21(DE3)/pLysS
Advenella mimigardefordensis
Engineering
Amino acid exchange
Commentary
Organism
additional information
transposon mutagenesis and deletion of gene sucCD, accumulation of 3SP during 3,3'-dithiodipropionic acid degradation occurs in Tn5::mob-induced mutants of Advenella mimigardefordensis strain DPN7T disrupted in sucCD and in the defined deletion mutant Advenella mimigardefordensis DELTAsucCD; transposon mutagenesis and deletion of gene sucCD, accumulation of 3SP during 3,3'-dithiodipropionic acid degradation occurs in Tn5::mob-induced mutants of Advenella mimigardefordensis strain DPN7T disrupted in sucCD and in the defined deletion mutant Advenella mimigardefordensis DELTAsucCD
Advenella mimigardefordensis
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
SucCDAm is Mg2+- or Mn2+-dependent; SucCDAm is Mg2+- or Mn2+-dependent
Advenella mimigardefordensis
Mn2+
SucCDAm is Mg2+- or Mn2+-dependent; SucCDAm is Mg2+- or Mn2+-dependent
Advenella mimigardefordensis
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
GTP + succinate + CoA
Advenella mimigardefordensis
SucCDAm is unspecific regarding ATP or GTP
GDP + phosphate + succinyl-CoA
-
-
?
GTP + succinate + CoA
Advenella mimigardefordensis DPN7T
SucCDAm is unspecific regarding ATP or GTP
GDP + phosphate + succinyl-CoA
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Advenella mimigardefordensis
B3TZD8
subunit beta; i.e. Tetrathiobacter mimigardefordensis, gene SucCDAm
-
Advenella mimigardefordensis
B3TZD9
subunit alpha; i.e. Tetrathiobacter mimigardefordensis, gene SucCDAm
-
Advenella mimigardefordensis DPN7T
B3TZD8
subunit beta; i.e. Tetrathiobacter mimigardefordensis, gene SucCDAm
-
Advenella mimigardefordensis DPN7T
B3TZD9
subunit alpha; i.e. Tetrathiobacter mimigardefordensis, gene SucCDAm
-
Purification (Commentary)
Commentary
Organism
recombinant soluble enzyme from Escherichia coli strain BL21(DE3)/pLysS by anion exchange chromatography; recombinant soluble enzyme from Escherichia coli strain BL21(DE3)/pLysS by anion exchange chromatography
Advenella mimigardefordensis
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
GTP + 3-sulfinopropionate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + 3-sulfinopropionyl-CoA
determination of 3-sulfinopropionyl-CoA structure by using liquid chromatography-electrospray ionization-mass spectrometry
-
-
?
GTP + 3-sulfinopropionate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + 3-sulfinopropionyl-CoA
determination of 3-sulfinopropionyl-CoA structure by using liquid chromatography-electrospray ionization-mass spectrometry
-
-
?
GTP + itaconate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + itaconyl-CoA
-
-
-
?
GTP + itaconate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + itaconyl-CoA
-
-
-
?
GTP + succinate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + succinyl-CoA
-
-
-
?
GTP + succinate + CoA
succinate is the best substrate, SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + succinyl-CoA
-
-
-
?
GTP + succinate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + succinyl-CoA
-
-
-
?
GTP + succinate + CoA
succinate is the best substrate, SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + succinyl-CoA
-
-
-
?
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
30
-
assay at; assay at
Advenella mimigardefordensis
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at; assay at
Advenella mimigardefordensis
Cofactor
Cofactor
Commentary
Organism
Structure
GTP
SucCDAm is unspecific regarding ATP or GTP; SucCDAm is unspecific regarding ATP or GTP
Advenella mimigardefordensis
Cloned(Commentary) (protein specific)
Commentary
Organism
gene sucCD, DNA and amino acid sequence determination and analysis, expression in Escherichia coli strain BL21(DE3)/pLysS
Advenella mimigardefordensis
gene sucCD, expression in Escherichia coli strain BL21(DE3)/pLysS
Advenella mimigardefordensis
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
GTP
SucCDAm is unspecific regarding ATP or GTP
Advenella mimigardefordensis
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
transposon mutagenesis and deletion of gene sucCD, accumulation of 3SP during 3,3'-dithiodipropionic acid degradation occurs in Tn5::mob-induced mutants of Advenella mimigardefordensis strain DPN7T disrupted in sucCD and in the defined deletion mutant Advenella mimigardefordensis DELTAsucCD
Advenella mimigardefordensis
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
SucCDAm is Mg2+- or Mn2+-dependent
Advenella mimigardefordensis
Mn2+
SucCDAm is Mg2+- or Mn2+-dependent
Advenella mimigardefordensis
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
GTP + succinate + CoA
Advenella mimigardefordensis
SucCDAm is unspecific regarding ATP or GTP
GDP + phosphate + succinyl-CoA
-
-
?
GTP + succinate + CoA
Advenella mimigardefordensis DPN7T
SucCDAm is unspecific regarding ATP or GTP
GDP + phosphate + succinyl-CoA
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant soluble enzyme from Escherichia coli strain BL21(DE3)/pLysS by anion exchange chromatography
Advenella mimigardefordensis
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
GTP + 3-sulfinopropionate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + 3-sulfinopropionyl-CoA
determination of 3-sulfinopropionyl-CoA structure by using liquid chromatography-electrospray ionization-mass spectrometry
-
-
?
GTP + 3-sulfinopropionate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + 3-sulfinopropionyl-CoA
determination of 3-sulfinopropionyl-CoA structure by using liquid chromatography-electrospray ionization-mass spectrometry
-
-
?
GTP + itaconate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + itaconyl-CoA
-
-
-
?
GTP + itaconate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + itaconyl-CoA
-
-
-
?
GTP + succinate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + succinyl-CoA
-
-
-
?
GTP + succinate + CoA
succinate is the best substrate, SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis
GDP + phosphate + succinyl-CoA
-
-
-
?
GTP + succinate + CoA
SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + succinyl-CoA
-
-
-
?
GTP + succinate + CoA
succinate is the best substrate, SucCDAm is unspecific regarding ATP or GTP
715381
Advenella mimigardefordensis DPN7T
GDP + phosphate + succinyl-CoA
-
-
-
?
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
30
-
assay at
Advenella mimigardefordensis
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
-
assay at
Advenella mimigardefordensis
Other publictions for EC 6.2.1.4
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
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6
1
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1
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1
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2
-
1
-
1
-
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-
1
-
-
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3
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1
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1
1
1
1
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2
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1
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1
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745500
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-
-
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3
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1
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3
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1
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1
1
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-
746174
Gomes
Succinyl-CoA synthetase New a ...
Bartonella bacilliformis
PLoS Negl. Trop. Dis.
10
e0004989
2016
-
-
-
-
-
-
-
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1
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3
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1
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1
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1
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1
1
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-
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-
-
-
-
-
-
-
743957
Huang
Structure of GTP-specific suc ...
Sus scrofa
Acta Crystallogr. Sect. F
71
1067-1071
2015
-
-
1
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
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1
1
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1
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1
1
1
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1
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1
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-
1
1
-
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-
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-
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-
-
-
-
-
-
745246
Dobolyi
Localization of SUCLA2 and SU ...
Homo sapiens
J. Bioenerg. Biomembr.
47
33-41
2015
-
-
-
-
-
-
-
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2
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2
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7
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2
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2
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2
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7
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2
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-
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-
745498
Luis
Valproyl-CoA inhibits the act ...
Homo sapiens
J. Inherit. Metab. Dis.
37
353-357
2014
-
-
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-
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3
1
1
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1
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727203
Li
Identification of the kinetic ...
Sus scrofa
Biosci. Rep.
33
145-163
2013
-
-
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1
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1
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1
1
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-
728078
Luis
Valproyl-CoA inhibits the acti ...
Homo sapiens
J. Inherit. Metab. Dis.
37
353-357
2013
-
-
-
-
-
-
3
-
1
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1
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1
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1
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1
1
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726583
Joyce
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Acta Crystallogr. Sect. D
68
751-762
2012
-
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1
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2
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2
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4
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1
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714342
Miller
The interplay between SUCLA2, ...
Homo sapiens
Biochim. Biophys. Acta
1812
625-629
2011
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1
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1
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2
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3
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715381
Schuermann
Novel reaction of succinyl coe ...
Advenella mimigardefordensis, Advenella mimigardefordensis DPN7T
J. Bacteriol.
193
3078-3089
2011
-
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1
-
1
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2
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-
6
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1
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16
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1
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16
-
2
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2
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687185
Fleige
Localisation of gluconeogenesi ...
Toxoplasma gondii
Int. J. Parasitol.
38
1121-1132
2008
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690760
Tsugawa
Alpha-ketoglutarate oxidoreduc ...
Helicobacter pylori
Biochem. Biophys. Res. Commun.
376
46-51
2008
-
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1
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1
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1
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693488
Ostergaard
Disorders caused by deficiency ...
Homo sapiens
J. Inherit. Metab. Dis.
31
226-229
2008
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1
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1
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4
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1
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5
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3
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3
1
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5
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8
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5
2
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