Literature summary for 6.2.1.33 extracted from

Gulick, A.M.; Lu, X.; Dunaway-Mariano, D.
Crystal structure of 4-chlorobenzoate:CoA ligase/synthetase in the unliganded and aryl substrate-bound states (2004), Biochemistry, 43, 8670-8679.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, 1.0 and 2.2 A. Crystal structures of the enzyme both in the unliganded state and bound to 4-chlorobenzoate. The space group is P3(1)21 or P3(2)21 with a = b = 129.3 A, c = 71.5 A	Alcaligenes sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
4-Chlorobenzoate + CoA + ATP	Alcaligenes sp.	the enzyme catalyzes the synthesis of 4-chlorobenzoyl-CoA, the first step in the 4-chlorobenzoate degradation pathway in 4-chlorobenzoate-degrading bacteria	4-Chlorobenzoyl-CoA + AMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Alcaligenes sp.	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Alcaligenes sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-Chlorobenzoate + CoA + ATP	the enzyme catalyzes the synthesis of 4-chlorobenzoyl-CoA, the first step in the 4-chlorobenzoate degradation pathway in 4-chlorobenzoate-degrading bacteria	Alcaligenes sp.	4-Chlorobenzoyl-CoA + AMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
CBAL	-	Alcaligenes sp.
chlorobenzoate:CoA ligase	-	Alcaligenes sp.

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Release 2023.1 (January 2023)