Literature summary for 6.2.1.30 extracted from

Meijer, W.H.; Gidijala, L.; Fekken, S.; Kiel, J.A.; van den Berg, M.A.; Lascaris, R.; Bovenberg, R.A.; van der Klei, I.J.
Peroxisomes are required for efficient penicillin biosynthesis in Penicillium chrysogenum (2010), Appl. Environ. Microbiol., 76, 5702-5709.

Cloned(Commentary)

Cloned (Comment)	Organism
for the visualization of peroxisomes by fluorescence microscopy, the peroxisomal targeting signal 1, PTS1, Ser-Lys-Leu, SKL, is fused to the extreme C-terminus of green fluorescent protein and DsRed, construction of plasmid pGBRH2-GFP-SKL, expression under the control of the strong Penicillium chrysogenum pcbC promoter, or by the lower-level, constitutive Aspergillus nidulans gpdA promoter in strain DS54465, an DELTAhdfA derivative of DS17690, transformation of protoplasts, overview	Penicillium chrysogenum

Cloned (Comment)

Organism

for the visualization of peroxisomes by fluorescence microscopy, the peroxisomal targeting signal 1, PTS1, Ser-Lys-Leu, SKL, is fused to the extreme C-terminus of green fluorescent protein and DsRed, construction of plasmid pGBRH2-GFP-SKL, expression under the control of the strong Penicillium chrysogenum pcbC promoter, or by the lower-level, constitutive Aspergillus nidulans gpdA promoter in strain DS54465, an DELTAhdfA derivative of DS17690, transformation of protoplasts, overview

Penicillium chrysogenum

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of peroxisome-deficient, non-oleate-utilizing mutants S2201 to S2204 from Wis54-1255 spores	Penicillium chrysogenum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	proliferation rates in strain DS17690, overview	Penicillium chrysogenum	5777	-
peroxisome	proliferation rates in strain NRRL1951, overview	Penicillium chrysogenum	5777	-
peroxisome	proliferation rates in strain Wis54-1255, overview	Penicillium chrysogenum	5777	-

Organism

Organism	UniProt	Comment	Textmining
Penicillium chrysogenum	-	-	-
Penicillium chrysogenum	-	a strain with increased penicillin production rate	-
Penicillium chrysogenum NRRL1951	-	-	-
Penicillium chrysogenum NRRL1951	-	a strain with increased penicillin production rate	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hypha	-	Penicillium chrysogenum	-
spore	germinating	Penicillium chrysogenum	-

Synonyms

Synonyms	Comment	Organism
PCL	-	Penicillium chrysogenum
phenylacetyl CoA ligase	-	Penicillium chrysogenum

Expression

Organism	Comment	Expression
Penicillium chrysogenum	Dnm1 and oleate suppress PCL and penicillin production	down

General Information

General Information	Comment	Organism
metabolism	PCL is essentially involved in the pathway of penicillin biosynthesis, overview. Conditions that lead to peroxisome proliferation but simultaneously interfere with the normal physiology of the cell may be detrimental to antibiotic production	Penicillium chrysogenum
additional information	conditions that lead to peroxisome proliferation but simultaneously interfere with the normal physiology of the cell may be detrimental for antibiotic production	Penicillium chrysogenum
additional information	conditions that lead to peroxisome proliferation but simultaneously interfere with the normal physiology of the cell may be detrimental for antibiotic production. The number of peroxisomes in a dnm1 overexpression strain variant is enhanced relative to those of wild-type controls	Penicillium chrysogenum
physiological function	PCL is a side-chain precursor activation enzyme essentially involved in the pathway of penicillin biosynthesis, overview	Penicillium chrysogenum