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Literature summary for 6.2.1.3 extracted from
- Inhibition of acyl-CoA synthetase by triacsins (1987), Biochim. Biophys. Acta, 921, 595-598.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Triacsin A | non-competitive with respect to ATP and coenzyme A | Pseudomonas aeruginosa |  |
| Triacsin A | non-competitive with respect to ATP and coenzyme A | Rattus norvegicus | |
| Triacsin C | - |
Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.041 | - |
linoleate | ATP, , oleate activation | Pseudomonas aeruginosa | |
| 0.101 | - |
oleic acid | - |
Pseudomonas aeruginosa | |
| 1.93 | - |
coenzyme A | oleate activation | Pseudomonas aeruginosa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + linoleate + CoA | - |
Pseudomonas aeruginosa | AMP + diphosphate + linoleoyl-CoA | - |
? | |
| ATP + oleate + CoA | - |
Rattus norvegicus | AMP + diphosphate + oleoyl-CoA | - |
? | |
| ATP + oleate + CoA | - |
Pseudomonas aeruginosa | AMP + diphosphate + oleoyl-CoA | - |
? | |
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Release 2023.1 (January 2023)
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