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Literature summary for 6.2.1.3 extracted from

  • Rosen, B.C.; Dillon, N.A.; Peterson, N.D.; Minato, Y.; Baughn, A.D.
    Long-chain fatty acyl coenzyme A ligase FadD2 mediates intrinsic pyrazinamide resistance in Mycobacterium tuberculosis (2017), Antimicrob. Agents Chemother., 61, e02130-16 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a long-chain fatty acid + CoA Mycobacterium tuberculosis
-
AMP + diphosphate + a long-chain acyl-CoA
-
?
ATP + a long-chain fatty acid + CoA Mycobacterium tuberculosis H37Rv
-
AMP + diphosphate + a long-chain acyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a long-chain fatty acid + CoA
-
Mycobacterium tuberculosis AMP + diphosphate + a long-chain acyl-CoA
-
?
ATP + a long-chain fatty acid + CoA
-
Mycobacterium tuberculosis H37Rv AMP + diphosphate + a long-chain acyl-CoA
-
?
ATP + laurate + CoA high activity Mycobacterium tuberculosis AMP + diphosphate + lauroyl-CoA
-
?
ATP + laurate + CoA high activity Mycobacterium tuberculosis H37Rv AMP + diphosphate + lauroyl-CoA
-
?
ATP + oleate + CoA high activity Mycobacterium tuberculosis AMP + diphosphate + oleoyl-CoA
-
?
ATP + oleate + CoA high activity Mycobacterium tuberculosis H37Rv AMP + diphosphate + oleoyl-CoA
-
?
ATP + palmitate + CoA highest activity Mycobacterium tuberculosis AMP + diphosphate + palmitoyl-CoA
-
?
ATP + palmitate + CoA highest activity Mycobacterium tuberculosis H37Rv AMP + diphosphate + palmitoyl-CoA
-
?
additional information the enzyme shows very low activity with acetate, propionate, butyrate, valerate, and caprylate Mycobacterium tuberculosis ?
-
?
additional information the enzyme shows very low activity with acetate, propionate, butyrate, valerate, and caprylate Mycobacterium tuberculosis H37Rv ?
-
?

Synonyms

Synonyms Comment Organism
FadD2
-
Mycobacterium tuberculosis
long-chain fatty acyl coenzyme A ligase
-
Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction enzyme deletion results in enhanced susceptibility to pyrazinoic acid and rifampin but not to isoniazid or ethambutol Mycobacterium tuberculosis