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Literature summary for 6.2.1.3 extracted from
- Role of long-chain acyl-coenzyme A synthetases in the regulation of arachidonic acid metabolism in interleukin 1beta-stimulated rat fibroblasts (2014), Biochim. Biophys. Acta, 1841, 44-53.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Triacsin C | - |
Rattus norvegicus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + arachidonate + CoA | Rattus norvegicus | preferred substrate | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| 3Y1 cell | - |
Rattus norvegicus | - |
| fibroblast | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + arachidonate + CoA | preferred substrate | Rattus norvegicus | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACSL | - |
Rattus norvegicus |
| ACSL1 | isoform | Rattus norvegicus |
| ACSL3 | isoform | Rattus norvegicus |
| ACSL4 | isoform | Rattus norvegicus |
| Long-chain acyl-coenzyme A synthetase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of endogenous Acsl4 expression increases significantly the release of arachidonate metabolites, including prostaglandin E2, prostaglandin D2, and prostaglandin F2alpha, compared with replicated control cells, whereas knockdown of Acsl1 expression reduces the interleukin-1beta-induced release of arachidonate metabolites | Rattus norvegicus |
| physiological function | Acsl isozymes play distinct roles in the control of arachidonate remodeling in rat fibroblasts: isoform Acsl4 acts as the first step of enzyme for arachidonate remodeling following interleukin-1beta stimulation, and isoform Acsl1 is involved in the maintenance of some arachidonate-containing phosphatidylcholine species | Rattus norvegicus |
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Release 2023.1 (January 2023)
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