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Literature summary for 6.2.1.3 extracted from
- Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation (2013), Biochem. Biophys. Res. Commun., 430, 272-277.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial membrane | - |
Mus musculus | 31966 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 74000 | - |
2 * 74000, SDS-PAGE | Mus musculus |
| 150000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + arachidonate + CoA | Mus musculus | preferred substrate | AMP + diphosphate + arachidonoyl-CoA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | the phosphorylation of the enzyme by protein kinase A and protein kinase C is hormone-dependent. Phosphorylation occurs after active dimer formation | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenocortical tumor cell | - |
Mus musculus | - |
| Y-1 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + arachidonate + CoA | preferred substrate | Mus musculus | AMP + diphosphate + arachidonoyl-CoA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | 2 * 74000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACSL4 | - |
Mus musculus |
| long-chain acyl-CoA synthetase 4 | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | long chain acyl CoA synthetase 4 is a key enzyme in steroidogenesis. It participates in steroid synthesis through of arachidonic acid release and steroidogenic acute regulatory protein induction | Mus musculus |
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Release 2023.1 (January 2023)
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