Literature summary for 6.2.1.3 extracted from

Zhang, Y.; Zhang, Y.; Gao, Y.; Zhao, X.; Wang, Z.
Drosophila long-chain acyl-CoA synthetase acts like a gap gene in embryonic segmentation (2011), Dev. Biol., 353, 259-265.

Search for more literature for 6.2.1.3

Cloned(Commentary)

Cloned (Comment)	Organism
dACS1, genotyping	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
K294E	naturally occuring mutant of dAcs1, K294E is located in the AMP-binding domain	Drosophila melanogaster
Q419R	naturally occuring mutant of dAcs1	Drosophila melanogaster
W685stop	naturally occuring mutant of dAcs1, W685stop removes the last 33 amino acids	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	isozyme dAcsl	-

Synonyms

Synonyms	Comment	Organism
ACSL	-	Drosophila melanogaster
dAcsl	-	Drosophila melanogaster
long-chain acyl-CoA synthetase	-	Drosophila melanogaster

General Information

General Information	Comment	Organism
malfunction	abdominal segmentation defects of dAcsl mutants resemble those of gap gene knirps. The central expression domain of Kni transcripts or proteins is reduced whereas the adjacent domains of another gap gene Hunchback are correspondingly expanded in these mutants. Consequently, the striped pattern of the pair-rule gene Even-skipped is disrupted, phenotype, overview	Drosophila melanogaster
physiological function	dAcsl is the Drosophila homolog of human ACSL4 and their functions are highly conserved in the processes ranging from lipid metabolism to the establishment of visual wiring, both maternal and zygotic dAcsl are required for embryonic segmentation	Drosophila melanogaster

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)