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Literature summary for 6.2.1.3 extracted from

  • Matsuda, D.; Namatame, I.; Ohshiro, T.; Ishibashi, S.; Omura, S.; Tomoda, H.
    Anti-atherosclerotic activity of triacsin C, an acyl-CoA synthetase inhibitor (2008), J. Antibiot., 61, 318-321.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Triacsin A isolated from the culture filtrate of Streptomyces sp. SK-1894, the anti-atherosclerotic agent acts as selective enzyme inhibitor, it inhibits the synthesis of cholesteryl ester and triacylglycerol in peritoneal macrophages Mus musculus
Triacsin C isolated from the culture filtrate of Streptomyces sp. SK-1894, the anti-atherosclerotic agent acts as selective enzyme inhibitor, it inhibits the synthesis of cholesteryl ester and triacylglycerol in peritoneal macrophages Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage peritoneal Mus musculus
-

Synonyms

Synonyms Comment Organism
ACS
-
Mus musculus
Acyl-CoA synthetase
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
inhibition of triacylglycerol synthesis Mus musculus Triacsin C
0.00016
-
inhibition of triacylglycerol synthesis Mus musculus Triacsin A
0.00018
-
inhibition of cholesteryl ester synthesis Mus musculus Triacsin A
0.00019
-
inhibition of cholesteryl ester synthesis Mus musculus Triacsin C