Literature summary for 6.2.1.20 extracted from

Takatani, N.; Use, K.; Kato, A.; Ikeda, K.; Kojima, K.; Aichi, M.; Maeda, S.; Omata, T.
Essential role of acyl-ACP synthetase in acclimation of the cyanobacterium Synechococcus elongatus strain PCC 7942 to high-light conditions (2015), Plant Cell Physiol., 56, 1608-1615 .

Search for more literature for 6.2.1.20

Application

Application	Comment	Organism
biofuel production	the enzyme might be useful for biofuel production using cyanobacteria	Synechococcus elongatus

Cloned(Commentary)

Cloned (Comment)	Organism
gene aas	Synechococcus elongatus

Protein Variants

Protein Variants	Comment	Organism
additional information	generation of an Aas-deficient mutant dAS1 of Synechococcus elongatus strain PCC 7942 by deleting an internal 667 bp from the gene aas coding region, phenotype, overview	Synechococcus elongatus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Synechococcus elongatus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + a long-chain fatty acid + an [acyl-carrier protein]	Synechococcus elongatus	-	AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]	-	?
ATP + a long-chain fatty acid + an [acyl-carrier protein]	Synechococcus elongatus PCC 7942	-	AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Synechococcus elongatus	-	-	-
Synechococcus elongatus PCC 7942	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a long-chain fatty acid + an [acyl-carrier protein]	-	Synechococcus elongatus	AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]	-	?
ATP + a long-chain fatty acid + an [acyl-carrier protein]	-	Synechococcus elongatus PCC 7942	AMP + diphosphate + a long-chain acyl-[acyl-carrier protein]	-	?

Synonyms

Synonyms	Comment	Organism
AAS	-	Synechococcus elongatus
Acyl-acyl carrier protein synthetase	-	Synechococcus elongatus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Synechococcus elongatus

General Information

General Information	Comment	Organism
malfunction	unlike wild-type cells, the aas-deficient cells of a mutant Synechococcus elongatus strain PCC 7942 cannot increase their growth rate as the light intensity is increased from 50 to 400 mmol photons m/s, and the high-light-grown mutant cells accumulate free fatty acids and the lysolipids derived from all the four major classes of membrane lipids, revealing high-light-induced lipid deacylation. The high-light-grown mutant cells show much lower photosystem PSII activity and Chl contents as compared with the wild-type cells or low-light-grown mutant cells. The loss of Aas accelerates photodamage of PSII but does not affect the repair process of PSII, indicating that PSII is destabilized in the mutant. Effects of high light and Aas deficiency on oligomerization state of photosystems. Phenotype, detailed overview	Synechococcus elongatus
physiological function	remodeling of membrane lipids is activated by high-intensity light and that the recycling of free fatty acids is essential for acclimation to highlight conditions involving the enzyme. Aas is essential for acclimation of the cyanobacterium to high-light conditions	Synechococcus elongatus

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Release 2023.1 (January 2023)