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Literature summary for 6.2.1.2 extracted from
- Formation of a free acyl adenylate during the activation of 2-propylpentanoic acid. Valproyl-AMP: a novel cellular metabolite of valproic acid (1992), J. Biol. Chem., 267, 3143-3146.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Octanoate | valproyl-AMP synthesis | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + valproic acid + CoA | i.e. 2-n-propylpentanoic acid | Rattus norvegicus | AMP + diphosphate + valproyl-CoA | - |
? | |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.8 | 8 | increase of activity when the pH increases from 6.8 to 8 | Rattus norvegicus |
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Release 2023.1 (January 2023)
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