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Literature summary for 6.2.1.17 extracted from
- Radioassay of acetyl-CoA synthetase, propionyl-CoA synthetase and butyryl-CoA synthetase in brain (1976), Anal. Biochem., 72, 614-622.
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | rapid radiochemical assay method with high sensitivity and specificity | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | 5 or 10 mM | Rattus norvegicus |  |
| GSH | 5 or 20 mM | Rattus norvegicus | |
| MgCl2 | above 10 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2.7 | - |
propanoate | - |
Rattus norvegicus | |
| 4.6 | - |
Butyrate | - |
Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | optimal concentration: 4.0 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + butyrate + CoA | - |
Rattus norvegicus | AMP + diphosphate + butyryl-CoA | - |
? | |
| ATP + propanoate + CoA | - |
Rattus norvegicus | AMP + diphosphate + propanoyl-CoA | - |
? | |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 37 | at 25°C the activity is 55% of that at 37°C | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
- |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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