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Literature summary for 6.2.1.16 extracted from

  • Bergstrom, J.D.; Edmond, J.
    Rat liver acetoacetyl-CoA synthetase (1985), Methods Enzymol., 110, 3-9.
    View publication on PubMed
Search for more literature for 6.2.1.16

Activating Compound

Activating Compound Comment Organism Structure
Tris stimulates Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Metals/Ions

Metals/Ions Comment Organism Structure
K+ monovalent cation required Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
100000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Rattus norvegicus
-
adrenal gland
-
 Rattus norvegicus
-
liver diurnal variation of activity with the peak in the middle of the dark cycle. Activity level is higher in femals than in males Rattus norvegicus
-
mammary gland lactating Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA 45% of the activity relative to acetoacetate Rattus norvegicus AMP + diphosphate + acetyl-CoA
-
 ?
ATP + acetoacetate + CoA no activity with GTP and CTP Rattus norvegicus AMP + diphosphate + acetoacetyl-CoA
-
 ?
ATP + L-3-hydroxybutanoate + CoA 20% of the activity relative to acetoacetate Rattus norvegicus AMP + diphosphate + L-3-hydroxybutyryl-CoA
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 phosphate buffer Rattus norvegicus
7.5
-
 Hepes buffer Rattus norvegicus