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Literature summary for 6.2.1.15 extracted from

  • Taylor, A.S.; Sprecher, H.; Russel, J.H.
    Characterization of an arachidonic acid-selective acyl-CoA synthetase from murine T lymphocytes (1985), Biochim. Biophys. Acta, 833, 229-238.
    View publication on PubMed
Search for more literature for 6.2.1.15

Inhibitors

Inhibitors Comment Organism Structure
5,8,11-eicosatrienoate
-
 Mus musculus
7,10,13,16-Docosatetraenoate
-
 Mus musculus
8,11,14-Eicosatrienoate
-
 Mus musculus
arachidonate inhibition of 5,8,11-eicosatrienoate activation and 8,11,13-eicosatrienoate activation; unlabeled arachidonate inhibits arachidonate activation Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 CoA
-
 Mus musculus
0.015
-
 arachidonate
-
 Mus musculus
0.029
-
 ATP
-
 Mus musculus
0.041
-
 5,8,11-eicosatrienoate
-
 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus
Mg2+ Km: 1.009 mM Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + arachidonate + CoA Mus musculus possible role in lymphocyte activation and as a homeostatic mechanism during essential fatty acid deficiency ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
EL4 cell
-
 Mus musculus
-
T-lymphocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5,8,11-eicosatrienoate + CoA
-
 Mus musculus AMP + diphosphate + 5,8,11-eicosatrienoyl-CoA
-
 ?
ATP + arachidonate + CoA
-
 Mus musculus AMP + diphosphate + arachidonoyl-CoA
-
 ?
ATP + arachidonate + CoA possible role in lymphocyte activation and as a homeostatic mechanism during essential fatty acid deficiency Mus musculus ?
-
 ?