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Literature summary for 6.2.1.13 extracted from

  • Chan, C.; Garrity, J.; Crosby, H.; Escalante-Semerena, J.
    In Salmonella enterica, the sirtuin-dependent protein acylation/deacylation system (SDPADS) maintains energy homeostasis during growth on low concentrations of acetate (2011), Mol. Microbiol., 80, 168-183.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
G266S the Acs mutant does not cause growth arrest in contrast to the wild-type enzyme Salmonella enterica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Salmonella enterica
-
 ADP + phosphate + acetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica
-
 gene acs
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA
-
 Salmonella enterica ADP + phosphate + acetyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
acetyl-coenzyme A synthetase
-
 Salmonella enterica
ACS
-
 Salmonella enterica

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Salmonella enterica

General Information

General Information Comment Organism
physiological function growth arrest is caused by elevated Acs, EC 6.2.1.1, activity, while overproduction of ADP-forming Ac-CoA synthesizing systems do not affect the growth behaviour of acetylation-deficient or acetylation-proficient strains Salmonella enterica