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Literature summary for 6.2.1.10 extracted from

  • Londesborough, J.C.; Webster, L.T.
    Fatty acyl-CoA synthetases (1974), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 10, 469-488.
No PubMed abstract available
Search for more literature for 6.2.1.10

Inhibitors

Inhibitors Comment Organism Structure
F- 2 mM, complete inhibition Rattus norvegicus
phosphate 5 mM, 70% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
 Octanoate
-
 Rattus norvegicus
0.22
-
 Butyrate
-
 Rattus norvegicus
2.1
-
 oleate
-
 Rattus norvegicus
3.3
-
 CoA
-
 Rattus norvegicus
3.3
-
 palmitate
-
 Rattus norvegicus
4.3
-
 GTP
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
 gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + butyrate + CoA
-
 Rattus norvegicus GDP + phosphate + butyryl-CoA
-
 ?
GTP + octanoate + CoA
-
 Rattus norvegicus GDP + phosphate + octanoyl-CoA
-
 ?
GTP + oleate + CoA
-
 Rattus norvegicus GDP + phosphate + oleoyl-CoA
-
 ?
GTP + palmitate + CoA
-
 Rattus norvegicus GDP + phosphate + palmitoyl-CoA
-
 ?
additional information the different specificity of the isolated GTP-dependent enzymes for fatty acid substrates results from their different lecithin contents Rattus norvegicus ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine contains 1 M 4´-phosphopantetheine per 20000 g enzyme Rattus norvegicus