Literature summary for 6.2.1.1 extracted from

Bulusu, V.; Tumanov, S.; Michalopoulou, E.; van den Broek, N.J.; MacKay, G.; Nixon, C.; Dhayade, S.; Schug, Z.T.; Vande Voorde, J.; Blyth, K.; Gottlieb, E.; Vazquez, A.; Kamphorst, J.J.
Acetate recapturing by nuclear acetyl-CoA synthetase 2 prevents loss of histone acetylation during oxygen and serum limitation (2017), Cell Rep., 18, 647-658 .

Search for more literature for 6.2.1.1

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + acetate + CoA	Homo sapiens	-	AMP + diphosphate + acetyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9NR19	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
AsPC-1 cell	-	Homo sapiens	-
BT-474 cell	-	Homo sapiens	-
HeLa cell	-	Homo sapiens	-
MDA-MB-231 cell	-	Homo sapiens	-
MDA-MB-468 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + acetate + CoA	-	Homo sapiens	AMP + diphosphate + acetyl-CoA	-	?

Synonyms

Synonyms	Comment	Organism
acetyl-CoA synthetase 2	-	Homo sapiens
ACSS2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	oxygen and serum limitation increase nuclear localization of isoform ACSS2	up

General Information

General Information	Comment	Organism
metabolism	isoform ACSS2 retains acetate to maintain histone acetylation	Homo sapiens

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Release 2023.1 (January 2023)