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Literature summary for 6.2.1.1 extracted from

  • Tan, X.; Martinho, M.; Stubna, A.; Lindahl, P.A.; Munck, E.
    Moessbauer evidence for an exchange-coupled {[Fe4S4]1+ Nip1+} a-cluster in isolated alpha subunits of acetyl-coenzyme A synthase/carbon monoxide dehydrogenase (2008), J. Am. Chem. Soc., 130, 6712-6713.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ the enzyme contains a ([Fe4S4]2+ Nip2+ Nid2+) cluster in the alpha-subunit, exchange coupling pathway between the Sc = 1/2 [Fe4S4]1+ cluster and the SNi = 1/2 Nip 1+ involves the cysteinate that links one cluster site, previously labeled FeD, to the Ni1+, structure and spectral analysis, overview Moorella thermoacetica
Mg2+
-
Moorella thermoacetica
Ni2+ the enzyme contains a ([Fe4S4]2+ Nip2+ Nid2+) cluster in the alpha-subunit, exchange coupling pathway between the Sc = 1/2 [Fe4S4]1+ cluster and the SNi = 1/2 Nip 1+ involves the cysteinate that links one cluster site, previously labeled FeD, to the Ni1+, structure and spectral analysis, overview Moorella thermoacetica

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Moorella thermoacetica
-
AMP + diphosphate + acetyl-CoA
-
?

Organism

Organism UniProt Comment Textmining
Moorella thermoacetica
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA reaction mechanism involving ([Fe4S4]2+ Nip2+ Nid2+) cluster Moorella thermoacetica

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA
-
Moorella thermoacetica AMP + diphosphate + acetyl-CoA
-
?

Subunits

Subunits Comment Organism
tetramer acetyl-coenzyme A synthase/carbon monoxide dehydrogenase is an alpha2beta2 tetramer, structure analysis, overview Moorella thermoacetica

Synonyms

Synonyms Comment Organism
acetyl-coenzyme A synthase/carbon monoxide dehydrogenase
-
Moorella thermoacetica

Cofactor

Cofactor Comment Organism Structure
ATP
-
Moorella thermoacetica