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Literature summary for 6.2.1.1 extracted from

  • Schwer, B.; Bunkenborg, J.; Verdin, R.O.; Andersen, J.S.; Verdin, E.
    Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2 (2006), Proc. Natl. Acad. Sci. USA, 103, 10224-10229.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion matrix Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + acetate + CoA Homo sapiens AceCS2 is reversibly acetylated at Lys642 in the active site of the enzyme. A mammalian sirtuin directly controls the activity of a metabolic enzyme by means of reversible lysine acetylation AMP + diphosphate + acetyl-CoA
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NUB1 acetyl-coenzyme A synthetase 2-like, mitochondrial. Precursor
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + acetate + CoA AceCS2 is reversibly acetylated at Lys642 in the active site of the enzyme. A mammalian sirtuin directly controls the activity of a metabolic enzyme by means of reversible lysine acetylation Homo sapiens AMP + diphosphate + acetyl-CoA
-
?

Synonyms

Synonyms Comment Organism
AceCS2
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Homo sapiens