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Literature summary for 6.1.1.7 extracted from
- Isolation of an alanine-activating enzyme from pig liver (1961), Biochim. Biophys. Acta, 49, 141-152.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-dichlorophenol-indophenol | enhances activity | Sus scrofa |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-mercaptoethanol | - |
Sus scrofa | |
| 2-mercaptoethylamine | - |
Sus scrofa | |
| L-cysteine | - |
Sus scrofa | |
| L-glutathione | - |
Sus scrofa | |
| p-Substituted mercuribenzoate | - |
Sus scrofa | |
| sulfhydryl group containing substances | - |
Sus scrofa | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Sus scrofa | 5737 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | or Mg2+ required | Sus scrofa | |
| Mg2+ | or Co2+ required | Sus scrofa | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Sus scrofa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Sus scrofa | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.027 | - |
alanyl-tRNA synthesis | Sus scrofa |
| 0.114 | - |
diphosphate-ATP exchange | Sus scrofa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-alanine + tRNAAla | marked specificity for ATP. ADP, GTP, ITP, CTP and UTP are inactive | Sus scrofa | AMP + diphosphate + L-alanyl-tRNAAla | - |
? | |
| additional information | synthesis of alanyl hydroxamate with high concentrations of hydroxylamine | Sus scrofa | ? | - |
? | |
| additional information | alanine dependent ATP-diphosphate exchange: alanine + ATP + enzyme /alanine-AMP-enzyme + diphosphate | Sus scrofa | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
alanyl-tRNA synthesis | Sus scrofa |
| 8.5 | - |
ATP-diphosphate exchange | Sus scrofa |
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