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Literature summary for 6.1.1.6 extracted from

  • Boulos, S.; Park, M.C.; Zeibak, M.; Foo, S.Y.; Jeon, Y.K.; Kim, Y.T.; Motzik, A.; Tshori, S.; Hamburger, T.; Kim, S.; Nechushtan, H.; Razin, E.
    Serine 207 phosphorylated lysyl-tRNA synthetase predicts disease-free survival of non-small-cell lung carcinoma (2017), Oncotarget, 8, 65186-65198 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.6

Activating Compound

Activating Compound Comment Organism Structure
epidermal growth factor receptor activation of LysRS by epidermal growth factor receptor (EGFR) Homo sapiens

Application

Application Comment Organism
diagnostics LysRS s207 phosphorylation plays a role as a prognostic factor in lung cancer after primary surgery Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Homo sapiens 5737
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15046
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein the MAPK-ERK pathway leads to the phosphorylation of LysRS on Ser207 and its release from the MSC in activated mast cells. Phosphorylation of Ser207 can be inhibited by U0126 treatment Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
cardiomyocyte
-
 Homo sapiens
-
HCC-827 cell
-
 Homo sapiens
-
mast cell
-
 Homo sapiens
-
additional information LysRS is ubiquitously found in tissues Homo sapiens
-
non-small cell lung carcinoma cell significantly higher staining levels of phosphos207-LysRS are observed in both the cytoplasm and the nuclei of cancerous tissues compared to healthy tissues Homo sapiens
-

Subunits

Subunits Comment Organism
More the enzyme is organized in a multi-synthetase complex (MSC) Homo sapiens

Synonyms

Synonyms Comment Organism
KARS
-
 Homo sapiens
LysRS
-
 Homo sapiens
Lysyl-tRNA synthetase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism LysRS enzyme phosphorylation on residue Ser207 is correlated to activity of epidermal growth factor receptor and level of lymph node metastases, e.g. in lung cancer, overview. The MAPK-ERK pathway leads to the phosphorylation of LysRS and its release from the MSC in activated mast cells. Lysyl-tRNA synthetase phosphorylated on Ser207 (P-s207 LysRS) is released from the cytoplasmic multi-tRNA synthetase complex (MSC) into the nucleus, where it activates the microphthalmia-associated transcription factor (MITF) in stimulated cultured mast cells and cardiomyocytes. This specific phosphorylation results in LysRS losing its ability to acetylate tRNA but enhances its production of the second messenger diadenosine tetraphosphate (Ap4A). Ap4A has been shown to bind to the tumor suppressor Hint-1, releasing its inhibition on MITF. Patients with EGFR mutations without lymph node metastases have a higher nuclear expression of Ser207 phosphorylated LysRS (50%) as compared to patients with lymph node metastases (27.8%) Homo sapiens
additional information the enzyme is organized in a multi-synthetase complex (MSC) Homo sapiens