Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.5 extracted from

  • Lee, J.; Kim, S.E.; Lee, J.Y.; Kim, S.Y.; Kang, S.U.; Seo, S.H.; Chun, M.W.; Kang, T.; Choi, S.Y.; Kim, H.O.
    N-Alkoxysulfamide, N-hydroxysulfamide, and sulfamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases (2003), Bioorg. Med. Chem. Lett., 13, 1087-1092.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-iodo-L-isoleucine-NHSO2-AMP highly potent inhibitor, hydrophobic interaction of the 2-substituent of the inhibitor with the adenine binding site of the enzyme Escherichia coli
isoleucyl sulfamate analogues
-
Escherichia coli
isoleucyl-N'-adenosyl-N'-hydroxy sulfamide
-
Escherichia coli
isoleucyl-N'-adenosyloxy sulfamide
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-isoleucine + tRNAIle Escherichia coli
-
AMP + diphosphate + L-isoleucyl-tRNAIle
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-isoleucine + tRNAIle
-
Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
-
?
ATP + L-isoleucine + tRNAIle formation of an aminoacyl adenylate reaction intermediate Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
-
?

Synonyms

Synonyms Comment Organism
IleRS
-
Escherichia coli
IRS
-
Escherichia coli
Isoleucine translase
-
Escherichia coli
Isoleucine--tRNA ligase
-
Escherichia coli
Isoleucine-transfer RNA ligase
-
Escherichia coli
Isoleucine-tRNA synthetase
-
Escherichia coli
Isoleucyl-transfer ribonucleate synthetase
-
Escherichia coli
Isoleucyl-transfer RNA synthetase
-
Escherichia coli
Isoleucyl-tRNA synthetase
-
Escherichia coli
Mupirocin resistance protein
-
Escherichia coli
Synthetase, isoleucyl-transfer ribonucleate
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information
-
Escherichia coli