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Literature summary for 6.1.1.5 extracted from

  • Auld, D.S.; Schimmel., P.
    Switching recognition of two tRNA synthetases with an amino acid swap in a designed peptide (1995), Science, 267, 1994-1996.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-isoleucine + tRNAIle the anticodon for methionine and isoleucine tRNAs differ by a single nucleotide, changing this nucleotide in an isoleucine tRNA is sufficient to change aminoacylation specificity to methionine Escherichia coli AMP + diphosphate + L-isoleucyl-tRNAIle
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