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Literature summary for 6.1.1.4 extracted from

  • Kim, C.; Jung, J.; Tung, T.T.; Park, S.B.
    beta-Turn mimetic-based stabilizers of protein-protein interactions for the study of the non-canonical roles of leucyl-tRNA synthetase (2016), Chem. Sci., 7, 2753-2761 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.4

Inhibitors

Inhibitors Comment Organism Structure
6,8-dibenzyl-2-(4-methylphenyl)-4,7-dioxo-N-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens
8-benzyl-6-[(4-chlorophenyl)methyl]-2-(4-methylphenyl)-4,7-dioxo-N-(prop-2-en-1-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens
8-benzyl-N-([1,1'-biphenyl]-2-yl)-2-methyl-4,7-dioxo-6-(propan-2-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens
additional information design and synthesis of tetra-substituted hexahydro-4H-pyrazino[2,1-c][1,2,4]triazine-4,7(6H)-diones as beta-turn mimetics via tandem N-acyliminium cyclization using a parallel synthetic strategy involving both solid and solution-phase reactions. Construction of a 162-member library of tetra-substituted pyrazinotriazinediones with an average purity of 90% using a solid-phase parallel synthesis platform, and screening for the LRS-RagD interaction inhibition by the compounds, overview Homo sapiens
N,8-dibenzyl-6-[(4-hydroxyphenyl)methyl]-2-methyl-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens
N-(4-fluorophenyl)-8-[(furan-2-yl)methyl]-2-methyl-4,7-dioxo-6-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)carbamimidamido]propyl]hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens
N-benzyl-8-butyl-2-(4-methylphenyl)-4,7-dioxo-6-(propan-2-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens
N-benzyl-8-butyl-6-[(4-chlorophenyl)methyl]-2-(4-methylphenyl)-4,7-dioxohexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens
N-benzyl-8-[(furan-2-yl)methyl]-2-(4-methylphenyl)-4,7-dioxo-6-(propan-2-yl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9P2J5
-
-

Synonyms

Synonyms Comment Organism
Leucyl-tRNA synthetase
-
 Homo sapiens
LRS
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism LRS-RagD interaction plays a pivotal role in the nutrientdependent mTORC1 signalling pathway Homo sapiens
additional information small-molecule protein-protein interactions modulators between LRS and RagD can be used as powerful research tools for studying the nutrient-dependent activation of mTORC1 and the subsequent biological outcome Homo sapiens
physiological function the direct interaction between enzyme LRS and RagD activates mTORC1 in live cells under leucine-deprived conditions. The nutrient sensing mechanism of mTORC1, particularly for Leu, an essential biomarker for nutrient status in cellular systems, is regulated by protein-protein interactions between LRS and RagD and directly mediate mTORC1 activation Homo sapiens