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Literature summary for 6.1.1.4 extracted from

  • Duran, R.V.; Hall, M.N.
    Leucyl-tRNA synthetase: double duty in amino acid sensing (2012), Cell Res., 22, 1207-1209.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-leucine + tRNALeu Homo sapiens
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
ATP + L-leucine + tRNALeu Saccharomyces cerevisiae
-
 AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-leucine + tRNALeu
-
 Homo sapiens AMP + diphosphate + L-leucyl-tRNALeu
-
 ?
ATP + L-leucine + tRNALeu
-
 Saccharomyces cerevisiae AMP + diphosphate + L-leucyl-tRNALeu
-
 ?

Synonyms

Synonyms Comment Organism
Leucyl-tRNA synthetase
-
 Homo sapiens
Leucyl-tRNA synthetase
-
 Saccharomyces cerevisiae
LRS
-
 Homo sapiens
LRS
-
 Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
physiological function the enzyme is a leucine sensor for serine/threonine kinase TORC1 and interacts with Gtr1 Saccharomyces cerevisiae
physiological function the enzyme is a leucine sensor for serine/threonine kinase TORC1 and interacts with Gtr2 Homo sapiens