Reference to 6.1.1.4; Id = 726909 - BRENDA Enzyme Database

expressed in Escherichia coli BL21(DE3) cells

Escherichia coli

E184A

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme

Escherichia coli

E184R

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme. The substitution specifically inhibits tRNA-dependent pre-transfer editing

Escherichia coli

E184R/T252R

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme

Escherichia coli

R185E

the mutation significantly enhances tRNA-dependent pre-transfer editing activity

Escherichia coli

R286E

the mutation significantly enhances tRNA-dependent pre-transfer editing activity

Escherichia coli

T252R

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme

Escherichia coli

0.002

-

Ile-tRNALeu

mutant enzyme R185E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.0021

-

Ile-tRNALeu

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.0024

-

Ile-tRNALeu

mutant enzyme R286E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.0025

-

Ile-tRNALeu

mutant enzyme E184R, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.039

-

L-leucine

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

ATP + L-leucine + tRNALeu

Escherichia coli

-

AMP + diphosphate + L-leucyl-tRNALeu

-

?

additional information

Escherichia coli

the enzyme has evolved both tRNA-dependent pre- and post-transfer editing capabilities to ensure catalytic specificity

?

-

?

Escherichia coli

P07813

-

Ni-NTA column chromatography

Escherichia coli

AMP + diphosphate + Ile-tRNALeu

-

726909

Escherichia coli

ATP + L-isoleucine + tRNALeu

-

?

ATP + L-leucine + tRNALeu

-

726909

Escherichia coli

AMP + diphosphate + L-leucyl-tRNALeu

-

?

additional information

the enzyme has evolved both tRNA-dependent pre- and post-transfer editing capabilities to ensure catalytic specificity

726909

Escherichia coli

?

-

?

Leucyl-tRNA synthetase

-

Escherichia coli

LeuRS

-

Escherichia coli

7

-

Ile-tRNALeu

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

7.4

-

Ile-tRNALeu

mutant enzyme R286E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

7.6

-

Ile-tRNALeu

mutant enzyme R185E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

8.8

-

Ile-tRNALeu

mutant enzyme E184R, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

73.7

-

L-leucine

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

ATP

-

Escherichia coli

expressed in Escherichia coli BL21(DE3) cells

Escherichia coli

ATP

-

Escherichia coli

E184A

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme

Escherichia coli

E184R

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme. The substitution specifically inhibits tRNA-dependent pre-transfer editing

Escherichia coli

E184R/T252R

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme

Escherichia coli

R185E

the mutation significantly enhances tRNA-dependent pre-transfer editing activity

Escherichia coli

R286E

the mutation significantly enhances tRNA-dependent pre-transfer editing activity

Escherichia coli

T252R

the mutant performs the activities of amino acid activation, aminoacylation and deacylation of mischarged tRNAs as well as the native enzyme

Escherichia coli

0.002

-

Ile-tRNALeu

mutant enzyme R185E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.0021

-

Ile-tRNALeu

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.0024

-

Ile-tRNALeu

mutant enzyme R286E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.0025

-

Ile-tRNALeu

mutant enzyme E184R, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

0.039

-

L-leucine

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

ATP + L-leucine + tRNALeu

Escherichia coli

-

AMP + diphosphate + L-leucyl-tRNALeu

-

?

additional information

Escherichia coli

the enzyme has evolved both tRNA-dependent pre- and post-transfer editing capabilities to ensure catalytic specificity

?

-

?

Ni-NTA column chromatography

Escherichia coli

AMP + diphosphate + Ile-tRNALeu

-

726909

Escherichia coli

ATP + L-isoleucine + tRNALeu

-

?

ATP + L-leucine + tRNALeu

-

726909

Escherichia coli

AMP + diphosphate + L-leucyl-tRNALeu

-

?

additional information

the enzyme has evolved both tRNA-dependent pre- and post-transfer editing capabilities to ensure catalytic specificity

726909

Escherichia coli

?

-

?

7

-

Ile-tRNALeu

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

7.4

-

Ile-tRNALeu

mutant enzyme R286E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

7.6

-

Ile-tRNALeu

mutant enzyme R185E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

8.8

-

Ile-tRNALeu

mutant enzyme E184R, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

73.7

-

L-leucine

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

1890

-

L-leucine

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3100

-

Ile-tRNALeu

mutant enzyme R286E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3300

-

Ile-tRNALeu

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3500

-

Ile-tRNALeu

mutant enzyme E184R, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3800

-

Ile-tRNALeu

mutant enzyme R185E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

1890

-

L-leucine

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3100

-

Ile-tRNALeu

mutant enzyme R286E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3300

-

Ile-tRNALeu

wild type enzyme, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3500

-

Ile-tRNALeu

mutant enzyme E184R, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

3800

-

Ile-tRNALeu

mutant enzyme R185E, in 100 mM HEPES (pH 7.8), 10 mM MgCl2, at 37Â°C

Escherichia coli

744849

Sato

Leucyl-tRNA synthetase is req ...

Mus musculus

Exp. Cell Res.

364

184-190

2018

-

1

-

1

-

1

-

1

-

2

-

4

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

4

-

1

-

2

-

745556

Dulic

Kinetic origin of substrate s ...

Escherichia coli

J. Mol. Biol.

430

1-16

2018

-

1

6

-

1

-

1

-

1

-

4

-

1

-

3

-

1

-

1

-

1

-

1

6

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

3

-

744247

Choi

Leucine-induced localization ...

Homo sapiens

Biochem. Biophys. Res. Commun.

493

1129-1135

2017

-

1

-

3

-

2

-

2

-

2

-

1

-

3

-

2

-

1

-

744654

Yoon

Leucyl-tRNA synthetase activa ...

Homo sapiens

Cell Rep.

16

1510-1517

2016

-

2

-

1

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

3

-

744693

Kim

beta-Turn mimetic-based stabi ...

Homo sapiens

Chem. Sci.

7

2753-2761

2016

-

9

-

1

-

1

-

2

-

9

-

1

-

3

-

745458

Gudzera

Identification of Mycobacteri ...

Mycobacterium tuberculosis, Homo sapiens, Mycobacterium tuberculosis ATCC 25618 / H37Rv

J. Enzyme Inhib. Med. Chem.

31

201-207

2016

-

1

2

-

57

-

1

-

1

-

11

-

2

-

1

-

6

2

-

2

-

1

-

1

2

1

-

57

-

1

-

1

-

2

-

1

-

2

-

2

-

1

-

744968

Giordano

The phenotypic expression of ...

Homo sapiens

Front. Genet.

6

113

2015

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

745321

Yan

Modulation of aminoacylation ...

Pyrococcus horikoshii, Aquifex aeolicus, Escherichia coli, Mycoplasma mobile, Homo sapiens, Mycoplasma mobile ATCC 43663 / 163K / NCTC 11711, Pyrococcus horikoshii ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3

J. Biol. Chem.

290

12256-12267

2015

-

5

-

24

-

31

1

5

-

7

-

13

-

5

-

17

1

17

5

-

29

5

-

5

-

5

-

24

-

31

1

5

-

7

-

5

-

17

1

5

-

29

5

-

13

-

29

745503

Kumar

Zinc is the molecular switch ...

Escherichia coli

J. Inorg. Biochem.

142

59-67

2015

-

1

-

5

-

1

-

2

-

1

-

3

-

1

-

1

5

1

-

1

-

1

-

1

-

5

-

1

-

2

-

1

-

1

-

1

-

1

-

3

-

727364

Perli

The isolated carboxy-terminal ...

Homo sapiens

EMBO Mol. Med.

6

169-182

2014

-

1

-

1

-

4

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

728409

Fang

Coexistence of bacterial leucy ...

Natrialba magadii, Natrialba magadii ATCC 43099

Nucleic Acids Res.

42

5109-5124

2014

-

1

-

1

8

1

2

-

6

-

1

-

10

2

3

-

8

2

-

1

-

1

-

1

-

8

1

2

-

1

-

10

2

-

8

2

-

1

-

8

744788

Perli

The isolated carboxy-terminal ...

Homo sapiens

EMBO Mol. Med.

6

169-182

2014

-

1

-

1

-

3

-

4

-

1

-

4

-

1

-

1

-

3

-

1

-

2

-

745112

Wang

Leucyl-tRNA synthetase regula ...

Bos taurus

Int. J. Mol. Sci.

15

5952-5969

2014

-

1

-

2

1

-

1

-

6

-

5

-

1

-

3

-

1

-

1

-

2

1

-

1

-

5

-

1

-

1

2

1

-

746422

Huang

A bridge between the aminoacy ...

Homo sapiens

RNA

20

1440-1450

2014

-

25

-

1

-

1

-

7

-

1

5

-

1

-

1

-

25

-

1

-

1

-

1

-

3

-

726909

Tan

Interdomain communication modu ...

Escherichia coli

Biochem. J.

449

123-131

2013

-

1

-

6

-

5

-

2

-

1

-

1

-

3

-

2

-

5

-

1

-

1

-

6

-

5

-

2

-

1

-

3

-

5

-

5

728402

Hu

Crucial role of the C-terminal ...

Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv

Nucleic Acids Res.

41

1859-1872

2013

-

1

-

11

-

12

-

1

2

-

191

-

1

-

2

1

2

1

-

12

1

-

1

-

1

-

11

-

12

-

1

2

-

1

-

2

1

-

12

1

-

12

728405

Yan

Leucine-specific domain modula ...

Mycoplasma mobile

Nucleic Acids Res.

41

4988-4998

2013

-

1

-

1

-

2

-

7

-

1

-

2

-

2

-

2

-

1

-

1

-

1

-

2

-

1

-

2

-

2

-

2

728693

Li

Leucyl-tRNA synthetase editing ...

Mycoplasma synoviae, Mycoplasma mobile

Proc. Natl. Acad. Sci. USA

110

3817-3822

2013

-

1

-

2

-

2

-

8

-

5

-

4

-

2

-

2

1

-

2

-

2

-

5

-

2

-

727276

Duran

Leucyl-tRNA synthetase: double ...

Saccharomyces cerevisiae, Homo sapiens

Cell Res.

22

1207-1209

2012

-

2

-

5

-

1

-

2

-

4

-

2

-

2

-

2

-

1

-

2

-

2

-

727281

Han

Leucyl-tRNA synthetase is an i ...

Homo sapiens

Cell

149

410-424

2012

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

715854

Ding

Design, synthesis, and structu ...

Trypanosoma brucei

J. Med. Chem.

54

1276-1287

2011

-

1

-

49

-

1

-

1

-

6

-

1

2

1

-

1

-

1

-

47

-

1

-

47

49

-

1

-

1

-

1

-

1

-

716384

Chen

Modular pathways for editing n ...

Homo sapiens

Nucleic Acids Res.

39

235-247

2011

-

1

-

1

-

3

1

2

-

9

-

1

-

2

-

3

1

-

2

1

-

1

-

1

-

1

-

3

1

2

-

1

-

2

-

1

-

2

1

-

1

-

2

704689

Tan

tRNA-dependent pre-transfer ed ...

Aquifex aeolicus, Escherichia coli

J. Biol. Chem.

285

3235-3244

2010

2

-

2

-

2

-

6

-

2

-

2

-

2

-

705705

Li

Human mitochondrial leucyl-tRN ...

Homo sapiens

Mol. Cell. Biol.

30

2147-2154

2010

-

1

-

2

-

6

-

1

-

1

-

2

-

1

-

714086

Zhou

Functional characterization of ...

Giardia intestinalis, Pyrococcus horikoshii

Biochem. J.

429

505-513

2010

-

2

-

38

-

83

-

2

-

2

-

4

-

2

-

4

2

4

2

-

82

2

-

2

-

2

-

38

-

83

-

2

-

2

-

2

-

4

2

-

82

2

-

4

-

82

714087

Zhou

Post-transfer editing by a euk ...

Giardia intestinalis

Biochem. J.

430

325-333

2010

-

1

-

6

-

2

5

-

1

-

1

-

4

-

2

-

2

-

5

2

-

1

-

1

-

6

-

2

-

5

-

1

-

1

-

2

-

2

-

5

2

-

2

-

5

714322

Montanari

Aminoacyl-tRNA synthetases are ...

Homo sapiens

Biochim. Biophys. Acta

1803

1050-1057

2010

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

714479

Gudzera

-

Functional role of C-terminal ...

Thermus thermophilus

Biopolym. Cell

26

478-485

2010

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

715277

Hagiwara

Editing mechanism of aminoacyl ...

Thermus thermophilus

J. Am. Chem. Soc.

132

2751-2758

2010

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

1

-

702063

Zhou

Two tyrosine residues outside ...

Giardia intestinalis

Biochem. Biophys. Res. Commun.

386

510-515

2009

-

6

-

11

-

6

-

3

-

11

-

6

-

11

-

3

-

11

-

11

702272

Zhou

A unique insertion in the CP1 ...

Giardia intestinalis

Biochemistry

48

1340-1347

2009

-

1

-

6

-

8

-

20

-

1

-

1

-

9

-

1

-

6

-

8

-

1

-

1

-

9

-

9

702347

Pang

A paradigm shift for the amino ...

Homo sapiens

Biochemistry

48

8958-8964

2009

-

3

-

4

3

-

4

-

3

-

4

-

3

-

4

3

-

3

-

4

-

4

703196

Tang

Introduction of an aliphatic k ...

Escherichia coli

ChemBioChem

10

2188-2190

2009

-

1

-

3

-

1

-

3

-

3

-

1

-

3

-

3

-

3

-

703725

Mascarenhas

A glycine hinge for tRNA-depen ...

Escherichia coli

FEBS Lett.

583

3443-3447

2009

-

6

-

1

-

6

-

703729

Hagiwara

Structural modelling of the co ...

Thermus thermophilus

FEBS Lett.

583

825-830

2009

-

1

-

1

-

1

-

704537

Boniecki

Leucyl-tRNA synthetase-depende ...

Saccharomyces cerevisiae

J. Biol. Chem.

284

26243-26250

2009

-

1

-

4

-

1

-

1

-

704595

Zhu

tRNA-independent pretransfer e ...

Aquifex aeolicus

J. Biol. Chem.

284

3418-3424

2009

-

1

-

1

-

4

-

3

-

4

-

4

-

1

-

1

-

4

-

4

-

4

-

1

-

4

705150

Seiradake

Crystal structures of the huma ...

Candida albicans, Homo sapiens

J. Mol. Biol.

390

196-207

2009

-

2

-

2

-

13

-

2

-

2

-

690955

Mascarenhas

Functional segregation of a pr ...

Escherichia coli

Biochemistry

47

4808-4816

2008

-

1

-

1

-

7

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

692229

Shin

Implication of leucyl-tRNA syn ...

Homo sapiens

Exp. Mol. Med.

40

229-236

2008

-

1

-

1

-

1

-

3

-

2

-

1

-

1

-

3

-

693109

Yao

Unique residues crucial for op ...

Homo sapiens, Saccharomyces cerevisiae

J. Biol. Chem.

283

22591-22600

2008

-

2

-

12

-

3

4

-

10

-

2

-

4

-

6

2

-

3

2

-

2

-

12

-

3

-

3

4

-

2

-

4

-

2

-

3

2

-

693164

Wang

Re-evaluating the roles of pro ...

Cricetulus griseus

J. Biol. Chem.

283

30482-30492

2008

-

1

-

6

-

1

-

1

-

1

-

1

-

693200

Zhou

The CP2 domain of leucyl-tRNA ...

Giardia intestinalis

J. Biol. Chem.

283

36608-36616

2008

-

1

-

15

-

1

-

11

-

1

-

1

-

2

1

-

1

-

1

-

15

-

1

-

1

-

1

-

1

-

1

-

693628

Hsu

A flexible peptide tether cont ...

Saccharomyces cerevisiae, Escherichia coli

J. Mol. Biol.

376

482-491

2008

-

2

-

19

-

8

-

2

-

2

-

4

2

-

2

-

2

-

19

-

2

-

2

-

2

-

2

-

693987

Staneviciene

Subacute effects of cadmium an ...

Mus musculus

Medicina (Kaunas)

44

131-138

2008

1

-

6

-

4

-

1

-

1

-

4

-

694435

Yao

Recognition of tRNALeu by Aqui ...

Aquifex aeolicus

Nucleic Acids Res.

36

2728-2738

2008

-

1

-

9

-

1

-

2

1

-

1

-

1

-

1

-

1

-

1

-

695107

Park

Overexpressed mitochondrial le ...

Homo sapiens

RNA

14

2407-2416

2008

-

1

-

1

-

4

-

1

-

1

-

1

-

672235

Zhai

Modulation of substrate specif ...

Escherichia coli

Biochemistry

46

3331-3337

2007

-

1

-

14

-

3

-

1

-

1

-

4

-

1

-

2

1

2

-

6

1

-

1

-

1

-

14

-

3

-

1

-

1

-

1

-

2

1

-

6

1

-

672244

Lue

A single residue in leucyl-tRN ...

Escherichia coli, Homo sapiens

Biochemistry

46

4466-4472

2007

-

6

-

14

2

-

2

-

8

-

2

-

8

-

4

2

-

15

2

-

2

-

2

-

6

-

14

2

-

2

-

2

-

8

-

2

-

15

2

-

672250

Fukunaga

The C-terminal domain of the a ...

Pyrococcus horikoshii

Biochemistry

46

4985-4996

2007

-

1

-

2

-

1

-

1

-

4

-

1

-

2

1

2

1

-

2

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

2

1

2

1

-

2

1

-

672252

Vu

A unique insert of leucyl-tRNA ...

Escherichia coli

Biochemistry

46

5170-5176

2007

1

-

1

-

1

-

3

-

1

-

1

-

3

-

1

-

1

-

2

-

2

1

-

2

1

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

2

-

1

-

2

1

-

672264

Betha

Isolated CP1 domain of Escheri ...

Escherichia coli

Biochemistry

46

6258-6267

2007

-

1

-

11

-

1

-

1

-

6

-

1

-

1

-

3

-

2

1

-

1

-

1

-

1

-

11

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

674875

Praetorius-Ibba

Functional association between ...

Methanothermobacter thermautotrophicus

J. Biol. Chem.

282

3680-3687

2007

1

-

1

-

1

-

1

-

1

-

11

-

1

-

2

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

675436

Nawaz

Molecular and functional disse ...

Saccharomyces cerevisiae

J. Mol. Biol.

367

384-394

2007

-

11

-

5

3

1

-

1

-

6

-

1

-

3

1

2

-

4

-

1

-

1

-

11

-

5

3

1

-

1

-

1

-

3

1

-

4

-

677102

Zhu

A present-day aminoacyl-tRNA s ...

Aquifex aeolicus

RNA

13

15-21

2007

-

1

-

1

-

1

-

1

-

7

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

2

-

1

-

661018

Liu

Crystal structures of the edit ...

Escherichia coli

Biochem. J.

394

399-407

2006

-

1

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

663318

Olieric

Expression, purification, and ...

Aquifex aeolicus

Protein Expr. Purif.

47

1-9

2006

-

1

-

1

-

13

-

1

-

2

-

1

-

1

-

1

-

2

-

672106

Ma

Split leucine-specific domain ...

Aquifex aeolicus

Biochemistry

45

14809-14816

2006

-

1

-

8

-

4

-

1

-

1

-

12

-

1

-

3

1

2

1

-

3

1

-

1

-

1

-

8

-

4

-

1

-

1

-

1

-

3

1

-

3

1

-

672507

Viezeliene

-

Effect of aluminum ions on the ...

Mus musculus

Biologija (Vilnius)

4

28-30

2006

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

674619

Hsu

Functional divergence of a uni ...

Saccharomyces cerevisiae, Escherichia coli

J. Biol. Chem.

281

23075-23082

2006

2

-

2

-

18

-

1

2

-

2

-

8

-

2

-

4

2

4

2

-

2

-

2

-

2

-

2

-

18

-

1

2

-

2

-

2

-

4

2

-

2

-

674686

Karkhanis

A viable amino acid editing ac ...

Saccharomyces cerevisiae

J. Biol. Chem.

281

33217-33225

2006

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1

-

3

-

3

1

-

1

-

8

-

1

-

2

-

2

1

-

1

-

1

-

1

-

3

-

3

1

-

1

-

1

-

2

-

1

-

1

-

661178

Zhai

Two conserved threonines colla ...

Escherichia coli

Biochemistry

44

15437-15443

2005

-

5

-

6

-

6

-

1

-

2

-

1

-

6

-

5

-

6

-

1

-

2

-

6

-

661190

Lue

An aminoacyl-tRNA synthetase w ...

Escherichia coli, Homo sapiens

Biochemistry

44

3010-3016

2005

-

4

1

-

6

-

4

-

1

-

4

-

4

1

-

4

-

4

-

661591

Zhao

Leucyl-tRNA synthetase from th ...

Aquifex aeolicus

EMBO J.

24

1430-1439

2005

-

1

-

1

-

14

-

1

-

1

-

1

-

1

-

1

-

1

-

662416

Ling

The C-terminal appended domain ...

Homo sapiens

J. Biol. Chem.

280

34755-34763

2005

-

1

-

10

5

-

1

-

8

-

1

-

2

1

-

10

-

1

-

10

5

-

1

-

1

-

2

1

-

10

-

662641

Fukunaga

Crystal structure of leucyl-tR ...

Pyrococcus horikoshii

J. Mol. Biol.

346

57-71

2005

-

1

-

14

-

1

-

3

-

1

-

1

-

3

-

662939

Tukalo

The crystal structure of leucy ...

Thermus thermophilus

Nat. Struct. Mol. Biol.

12

923-930

2005

-

1

-

3

-

1

-

660871

Xu

Groups on the side chain of T2 ...

Escherichia coli

Biochem. Biophys. Res. Commun.

318

11-16

2004

-

3

-

9

-

6

-

1

-

2

-

2

-

9

-

3

-

9

-

1

-

2

-

9

-

661109

Mursinna

Molecular dissection of a crit ...

Escherichia coli

Biochemistry

43

155-165

2004

-

3

-

8

-

3

-

1

-

8

-

3

-

8

-

1

-

8

-

662245

Xu

Leucyl-tRNA synthetase from th ...

Aquifex aeolicus

J. Biol. Chem.

279

32151-32158

2004

-

3

-

15

-

4

-

3

-

3

-

4

-

3

-

662619

Sohm

Recognition of human mitochond ...

Homo sapiens

J. Mol. Biol.

339

17-29

2004

-

2

3

-

6

-

1

-

1

-

2

3

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1

-

1

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662970

Zheng

Two distinct domains of the be ...

Aquifex aeolicus

Nucleic Acids Res.

32

3294-3303

2004

-

1

-

12

-

13

-

8

-

1

-

1

-

13

-

1

-

12

-

13

-

1

-

1

-

13

-

663301

Ling

High-level expression and sing ...

Aquifex aeolicus

Protein Expr. Purif.

36

146-149

2004

-

1

-

6

-

12

-

1

-

1

-

1

-

6

-

1

-

6

-

1

-

1

-

1

-

6

-

663351

Lee

Molecular modeling study of th ...

Escherichia coli

Proteins

54

693-704

2004

-

1

-

9

-

1

-

1

-

721148

Fukunaga

Crystallization and preliminar ...

Pyrococcus horikoshii

Acta Crystallogr. Sect. D

60

1916-1918

2004

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1

-

1

-

14

-

1

-

1

2

-

1

-

1

-

1

-

1

-

1

-

721175

Fukunaga

Crystallization of leucyl-tRNA ...

Pyrococcus horikoshii

Acta Crystallogr. Sect. F

61

30-32

2004

-

1

-

12

-

2

-

1

-

1

-

650221

Zhao

Enzymes assembled from Aquifex ...

Aquifex aeolicus, Escherichia coli

Biochemistry

42

7694-7700

2003

-

2

-

2

-

2

-

2

-

8

-

6

-

4

-

16

-

1

-

2

-

2

-

2

-

2

-

2

-

6

-

4

-

1

-

653045

Du

E292 is important for the amin ...

Escherichia coli

J. Protein Chem.

22

71-76

2003

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1

-

6

-

1

14

-

1

-

6

-

1

-

7

-

1

-

8

1

-

20

1

-

1

-

1

-

6

-

1

-

14

-

1

-

1

-

7

-

1

-

1

-

20

1

-

653192

Lincecum

Structural and mechanistic bas ...

Saccharomyces cerevisiae, Escherichia coli, Thermus thermophilus

Mol. Cell

11

951-963

2003

-

2

1

4

-

1

-

1

-

3

-

3

-

2

3

-

10

-

25

-

3

-

3

-

2

3

1

4

-

1

-

1

-

3

-

2

-

10

-

3

-

653766

Yao

Human mitochondrial leucyl-tRN ...

Homo sapiens

Protein Expr. Purif.

30

112-116

2003

-

1

-

3

7

-

1

-

11

-

1

-

2

-

2

-

8

1

-

3

-

1

-

1

-

3

7

-

1

-

1

-

2

-

2

-

1

-

3

-

649605

Gouda

The beta-subunit of Aquifex ae ...

Aquifex aeolicus

Biochem. Biophys. Res. Commun.

297

950-955

2002

-

1

-

3

1

-

6

-

1

-

1

-

3

2

8

-

1

-

1

-

1

-

3

1

-

1

-

3

2

-

1

-

650097

Tang

Attenuation of the editing act ...

Escherichia coli

Biochemistry

41

10635-10645

2002

-

1

-

3

-

8

-

6

-

1

-

10

-

8

1

-

2

-

1

-

1

-

3

-

8

-

1

-

10

-

1

-

2

-

651299

Gouda

Leucyl-tRNA synthetase from th ...

Aquifex aeolicus

FEBS Lett.

518

139-143

2002

-

1

-

4

-

3

1

-

9

-

1

-

1

-

4

1

8

-

4

-

1

-

1

-

4

-

3

1

-

1

-

4

1

-

4

-

652320

Xu

Leucyl-tRNA synthetase consist ...

Aquifex aeolicus

J. Biol. Chem.

277

41590-41596

2002

-

1

-

12

-

1

3

1

-

15

-

1

-

5

2

8

1

-

2

12

1

-

1

-

1

-

12

-

1

3

1

-

1

-

5

2

1

-

2

12

1

-

650024

Chen

Effect of alanine-293 replacem ...

Escherichia coli

Biochemistry

40

1144-1149

2001

-

1

-

10

-

1

-

1

-

9

-

1

-

8

-

2

-

8

1

-

3

4

1

-

1

-

1

-

10

-

1

-

1

-

1

-

8

-

2

-

1

-

3

4

1

-

649136

Yaremchuk

Crystallization and preliminar ...

Thermus thermophilus

Acta Crystallogr. Sect. D

56

667-669

2000

-

1

-

1

-

6

-

1

-

9

-

1

-

1

-

1

-

1

-

649992

Chen

CP1 domain in Escherichia coli ...

Escherichia coli

Biochemistry

39

6726-6731

2000

-

1

-

1

-

11

-

1

-

4

-

1

-

2

-

5

1

8

1

-

12

1

-

1

-

1

-

1

-

11

-

1

-

1

-

2

-

5

1

-

12

1

-

650328

Bullard

Expression and characterizatio ...

Homo sapiens

Biochim. Biophys. Acta

1490

245-258

2000

-

1

-

1

3

5

-

1

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3

1

10

1

-

3

1

-

1

-

1

-

1

-

3

5

-

1

-

3

1

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3

1

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652046

Nathanson

Active aminoacyl-tRNA syntheta ...

Cricetulus griseus

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275

31559-31562

2000

-

2

-

2

-

1

-

1

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8

1

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1

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1

-

1

-

2

-

2

-

1

-

3

-

1

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1

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649867

Li

The peptide bond between E292- ...

Escherichia coli

Biochemistry

38

13063-13069

1999

-

1

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3

1

-

6

-

1

-

1

3

1

8

1

-

2

-

1

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1

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3

1

-

1

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1

3

1

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652803

Soma

Unique recognition style of tR ...

Haloferax volcanii

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293

1029-1038

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1

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1

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4

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1

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1

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5

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1

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1

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653716

Chen

High-level expression and sing ...

Escherichia coli

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115-120

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1

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1

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4

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1

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1

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2

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6

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The multienzyme complex contai ...

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Membrane association of leucyl ...

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794-800

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Cloning and nucleotide sequenc ...

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Characteristics of a leucine a ...

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Homology of yeast mitochondria ...

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The NAM2 proteins from S. cere ...

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Biochemical comparison of the ...

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6

-

1

-

1

2

-

1

2

-

6

1

5

-

1

-

1

2

-

1

2

-

434

Colas

Chloroplastic and cytoplasmic ...

Euglena gracilis

Biochim. Biophys. Acta

697

71-77

1982

-

2

-

2

-

2

-

1

-

1

-

1

2

-

2

-

2

-

2

-

1

-

1

2

-

435

Souciet

Purification and properties of ...

Phaseolus vulgaris

J. Biol. Chem.

257

9598-9604

1982

-

4

7

1

2

-

16

-

1

-

1

-

1

-

1

-

4

7

1

2

-

1

-

1

-

1

-

1

-

436

Imbault

-

Properties of purified chlorop ...

Euglena gracilis

Phytochemistry

21

1189-1193

1982

1

-

2

4

-

1

-

1

-

1

-

2

4

-

1

-

151

Wright

Naldixic acid, oxolinic acid, ...

Saccharomyces cerevisiae

Science

213

455-456

1981

-

3

2

-

1

-

1

-

3

-

2

-

1

-

432

Imbault

Chloroplast leucyl-tRNA synthe ...

Euglena gracilis

Biochemistry

20

5855-5859

1981

-

3

6

8

2

-

8

-

1

-

4

1

-

1

-

1

-

3

6

8

2

-

1

-

4

1

-

1

-

1

-

433

Sarantoglou

-

Purification of Euglena gracil ...

Euglena gracilis

Plant Sci. Lett.

22

291-297

1981

-

3

-

1

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

274

Carias

Leucyl-tRNA and arginyl-tRNA s ...

Triticum aestivum

Eur. J. Biochem.

87

583-590

1978

-

1

-

2

-

1

-

1

-

2

1

-

1

-

2

-

1

-

2

1

-

429

Marutzky

ATP-analogue as substrates for ...

Escherichia coli, Escherichia coli MRE 600

Nucleic Acids Res.

3

2067-2077

1976

-

14

7

-

32

-

13

-

14

-

7

-

13

-

426

Murasugi

Purification and properties of ...

Cyberlindnera jadinii, Cyberlindnera jadinii Torulopsis

Eur. J. Biochem.

57

169-175

1975

-

1

2

-

3

-

5

-

1

-

1

-

2

1

-

1

-

1

-

2

-

3

-

1

-

1

-

2

1

-

1

-

427

Chiu

The absence of structural rela ...

Tetrahymena pyriformis

Arch. Biochem. Biophys.

171

43-54

1975

-

1

2

-

1

-

1

-

1

-

2

1

-

2

-

1

2

-

1

-

1

2

1

-

2

-

428

Lin

Kinetic studies of leucyl tran ...

Saccharomyces cerevisiae

J. Biol. Chem.

250

9299-9303

1975

-

1

2

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

425

Nathan

Leucyl-transfer ribonucleic ac ...

Nicotiana rustica

Biochem. J.

140

169-173

1974

-

3

-

1

-

1

-

1

-

1

-

424

Chirikjian

Purification and properties of ...

Saccharomyces cerevisiae

J. Biol. Chem.

248

1074-1079

1973

-

1

5

3

-

4

1

-

3

-

1

-

1

2

1

-

1

-

1

-

1

-

1

-

5

-

3

-

4

1

-

1

-

1

2

1

-

1

-

1

-

422

Berg

-

The enzymic synthesis of amino ...

Escherichia coli

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1726-1734

1961

-

1

-

1

-

1

-

1

-

531

Bergmann

-

The Enzymic synthesis of amino ...

Escherichia coli

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1735-1740

1961

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

3

-

1

-

Interdomain communication modulates the tRNA-dependent pre-transfer editing of leucyl-tRNA synthetase

Data extracted from this reference: