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Literature summary for 6.1.1.4 extracted from

  • Viezeliene, D.; Rodovicius, H.; Ivanov, L.
    Effect of aluminum ions on the activities of tRNALeu and leucyl-tRNA synthetase in mouse liver in vivo and in vitro (2006), Biologija (Vilnius), 4, 28-30.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
Al3+ in vivo acceptor activity of tRNALeu is decreased by 23% thereby the leucyl-tRNA synthetase activity is increased by 20%, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
Al3+ in vitro the enzyme is inhibited by 40% at 0.04 mM, Al3+ inhibits the enzyme in vivo and in vitro, quantitative analysis, in vivo acceptor activity of tRNALeu is decreased by 23% thereby the leucyl-tRNA synthetase activity is increased by 20%, overview Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-leucine + tRNALeu Mus musculus
-
AMP + diphosphate + L-leucyl-tRNALeu
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-leucine + tRNALeu
-
Mus musculus AMP + diphosphate + L-leucyl-tRNALeu
-
?

Synonyms

Synonyms Comment Organism
Leucyl-tRNA synthetase
-
Mus musculus
LeuRS
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus