Literature summary for 6.1.1.3 extracted from

Wellman, T.L.; Eckenstein, M.; Wong, C.; Rincon, M.; Ashikaga, T.; Mount, S.L.; Francklyn, C.S.; Lounsbury, K.M.
Threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer (2014), BMC Cancer, 14, 620 .

Search for more literature for 6.1.1.3

Application

Application	Comment	Organism
diagnostics	enzyme TARS is a regulator of the tumor microenvironment and possible target for diagnosis and/or treatment in ovarian cancer. The enzyme has a potential value as an ovarian cancer diagnostic	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	enzyme TARS is secreted from ovarian cancer cells in response to cell stress	Homo sapiens	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	required	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-threonine + tRNAThr	Homo sapiens	-	AMP + diphosphate + L-threonyl-tRNAThr	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P26639	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovarian cancer cell	ovarian tissues from 70 patients diagnosed with epithelial ovarian cancer and 12 control patients are assessed for expression of TARS, vascular endothelial growth factor (VEGF), and platelet endothelial cell adhesion molecule (PECAM) using immunohistochemistry. TARS is overexpressed in infiltrating leukocytes within ovarian tumors	Homo sapiens	-
SK-OV-3 cell	TARS secretion from SK-OV-3 human ovarian cancer cells	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-threonine + tRNAThr	-	Homo sapiens	AMP + diphosphate + L-threonyl-tRNAThr	-	?

Synonyms

Synonyms	Comment	Organism
TarS	-	Homo sapiens
Threonyl-tRNA synthetase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	TARS expression is increased in epithelial ovarian cancer and correlates with markers of angiogenic progression. TARS is overexpressed in infiltrating leukocytes within ovarian tumors	up

General Information

General Information	Comment	Organism
malfunction	threonyl-tRNA synthetase overexpression correlates with angiogenic markers and progression of human ovarian cancer	Homo sapiens
physiological function	threonyl-tRNA synthetase (TARS) has an extracellular angiogenic activity separate from its function in protein synthesis. Strong association between the tumor expression of TARS and advancing stage of epithelial ovarian cancer, TARS expression and localization are also correlated with vascular endothelial growth factor (VEGF). Enzyme TARS is a regulator of the tumor microenvironment. TARS is secreted from ovarian cancer cells in response to cell stress	Homo sapiens

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Release 2023.1 (January 2023)