Literature summary for 6.1.1.27 extracted from

Chen, M.; Kato, K.; Kubo, Y.; Tanaka, Y.; Liu, Y.; Long, F.; Whitman, W.B.; Lill, P.; Gatsogiannis, C.; Raunser, S.; Shimizu, N.; Shinoda, A.; Nakamura, A.; Tanaka, I.; Yao, M.
Structural basis for tRNA-dependent cysteine biosynthesis (2017), Nat. Commun., 8, 1521 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli B834(DE3) cells	Methanocaldococcus jannaschii

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 0.1 M Tris-HCl pH 7.0, 0.3M ammonium sulfate, 36% (w/v) 2-methyl-2,4-pentanediol	Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + O-phospho-L-serine + tRNACys	Methanocaldococcus jannaschii	-	AMP + diphosphate + O-phospho-L-seryl-tRNACys	-	?

Organism

Organism	UniProt	Comment	Textmining
Methanocaldococcus jannaschii	Q59054	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + O-phospho-L-serine + tRNACys	-	Methanocaldococcus jannaschii	AMP + diphosphate + O-phospho-L-seryl-tRNACys	-	?

Subunits

Subunits	Comment	Organism
homotetramer	-	Methanocaldococcus jannaschii

Synonyms

Synonyms	Comment	Organism
O-phosphoseryl-tRNA synthetase	-	Methanocaldococcus jannaschii
SepRS	-	Methanocaldococcus jannaschii
sepS	-	Methanocaldococcus jannaschii

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Methanocaldococcus jannaschii

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Release 2023.1 (January 2023)