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Literature summary for 6.1.1.21 extracted from
- Evolutionary gain of highly divergent tRNA specificities by two isoforms of human histidyl-tRNA synthetase (2017), Cell. Mol. Life Sci., 74, 2663-2677 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bacillus subtilis | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-histidine + tRNAHis | Bacillus subtilis | - |
AMP + diphosphate + L-histidyl-tRNAHis | - |
? |  |
| ATP + L-histidine + tRNAHis | Homo sapiens | - |
AMP + diphosphate + L-histidyl-tRNAHis | - |
? | |
| ATP + L-histidine + tRNAHis | Saccharomyces cerevisiae | - |
AMP + diphosphate + L-histidyl-tRNAHis | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Bacillus subtilis |
| Ni-NTA column chromatography | Homo sapiens |
| Ni-NTA column chromatography | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-histidine + tRNAHis | - |
Bacillus subtilis | AMP + diphosphate + L-histidyl-tRNAHis | - |
? | |
| ATP + L-histidine + tRNAHis | - |
Homo sapiens | AMP + diphosphate + L-histidyl-tRNAHis | - |
? | |
| ATP + L-histidine + tRNAHis | - |
Saccharomyces cerevisiae | AMP + diphosphate + L-histidyl-tRNAHis | - |
? | |
| additional information | the enzyme recognizes only tRNAHis with cytosine73 but not with adenine73 | Bacillus subtilis | ? | - |
? | |
| additional information | the enzyme recognizes tRNAHis with cytosine73 or adenine73 | Homo sapiens | ? | - |
? | |
| additional information | the enzyme recognizes tRNAHis with cytosine73 or adenine73 and a slight preference for adenine7 | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HisRS | - |
Bacillus subtilis |
| HisRS | - |
Homo sapiens |
| HisRS | - |
Saccharomyces cerevisiae |
| Histidyl-tRNA synthetase | - |
Bacillus subtilis |
| Histidyl-tRNA synthetase | - |
Homo sapiens |
| Histidyl-tRNA synthetase | - |
Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Bacillus subtilis | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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