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Literature summary for 6.1.1.21 extracted from

  • Abbott, J.A.; Guth, E.; Kim, C.; Regan, C.; Siu, V.M.; Rupar, C.A.; Demeler, B.; Francklyn, C.S.; Robey-Bond, S.M.
    The Usher Syndrome Type IIIB histidyl-tRNA synthetase mutation confers temperature sensitivity (2017), Biochemistry, 56, 3619-3631 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
Y454S the mutation is associated with childhood deafness, blindness, and episodic hallucinations during acute illness Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-histidine + tRNAHis Homo sapiens
-
AMP + diphosphate + L-histidyl-tRNAHis
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-histidine + tRNAHis
-
Homo sapiens AMP + diphosphate + L-histidyl-tRNAHis
-
?

Synonyms

Synonyms Comment Organism
HARS
-
Homo sapiens
Histidyl-tRNA synthetase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens