Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Mus musculus | - |
lung | - |
Homo sapiens | - |
muscle | - |
Mus musculus | - |
muscle | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HisRS | - |
Mus musculus |
HisRS | - |
Homo sapiens |
histidyl-transfer RNA synthetase | - |
Mus musculus |
histidyl-transfer RNA synthetase | - |
Homo sapiens |
Jo-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | in idiopathic inflammatory myopathy, the aminoacyl-transfer RNA synthetases are targets of the autoimmune response. Among these antigens, antibodies against histidyl-transfer RNA synthetase are by far the most prominent found in 15-20% of myositis patients, and more strikingly, are detected in about 70% of patients with myositis and interstitial lung disease. Strong association of HisRS with interstitial lung disease in humans | Homo sapiens |
additional information | mouse HisRS without adjuvant, containing Toll-like receptor TLR-4, can induce sustained muscle inflammation and an adaptive immune response to HisRS. Mice lacking TLR-4 show that the ability of mouse HisRS to produce muscle inflammation does not require TLR-4 signaling, nor is it dependent on recognition of B cell and T cell receptors. When TLR-4-deficient animals are immunized with HisRS, they have a preserved inflammatory response in muscle but fail to generate a HisRS antibody response | Mus musculus |