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Literature summary for 6.1.1.21 extracted from

  • Fahoum, S.K.; Yang, D.C.H.
    Purification of mammalian histidyl-tRNA synthetase and its interaction with myositis-specific anti-Jo-1 antibodies (1987), Biochemistry, 26, 5871-5877.
    View publication on PubMed
Search for more literature for 6.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
Myositis-specific anti-Jo-1 autoantibody
-
 Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 2 * 50000, SDS-PAGE Rattus norvegicus
96000
-
 gel filtration, measurement of the sedimentation coefficient Rattus norvegicus
115000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus 1. plays an important role in the regulation of protein degradation as well as in protein biosynthesis. 2. involvement of tRNAHis and possibly histidyl-tRNA synthetase in a nonlysosomal ubiquitin-dependent and ATP-dependent protein degradation pathway. 3. involvement in autoimmune diseases ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Rattus norvegicus

Renatured (Commentary)

Renatured (Comment) Organism
denaturation with SDS, renatured enzyme shows 10% recovery of activity Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-histidine + tRNAHis
-
 Rattus norvegicus AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
additional information 1. plays an important role in the regulation of protein degradation as well as in protein biosynthesis. 2. involvement of tRNAHis and possibly histidyl-tRNA synthetase in a nonlysosomal ubiquitin-dependent and ATP-dependent protein degradation pathway. 3. involvement in autoimmune diseases Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 50000, SDS-PAGE Rattus norvegicus