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Literature summary for 6.1.1.21 extracted from

  • Yang, D.C.H.; Dang, C.V.; Arnett, F.C.
    Rat liver histidyl-tRNA synthetase. Purification and inhibition by the myositis-specific anti-Jo-1 autoantibody (1984), Biochem. Biophys. Res. Commun., 120, 15-21.
    View publication on PubMed

Application

Application Comment Organism
medicine purified Jo-1 antigen will be useful in determining the role of anti-Jo-1 in the pathogenesis of polymyositis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Myositis-specific anti-Jo-1 autoantibody
-
Homo sapiens
Myositis-specific anti-Jo-1 autoantibody
-
Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000
-
2 * 64000, SDS-PAGE Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.618
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-histidine + tRNAHis
-
Homo sapiens AMP + diphosphate + L-histidyl-tRNAHis
-
?
ATP + L-histidine + tRNAHis
-
Rattus norvegicus AMP + diphosphate + L-histidyl-tRNAHis
-
?

Subunits

Subunits Comment Organism
dimer 2 * 64000, SDS-PAGE Rattus norvegicus