Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PheOH-AMP | - |
Homo sapiens | |
tRNAPhe Cp75 | tRNAPhe with cytosine phosphate residue at position 75 | Homo sapiens | |
tRNAPhe s4-U75 | tRNAPhe with 4-thiouridine residue at position 75 | Homo sapiens | |
tRNAPhe s4-U76 | tRNAPhe with 4-thiouridine residue at position 76 | Homo sapiens | |
tRNAPhe s4-U77 | tRNAPhe with 4-thiouridine residue at position 77 | Homo sapiens | |
tRNAPhe s4-Up77 | tRNAPhe with 4-thiouridine phosphate residue at position 77 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
L-phenylalanine | 25°C | Homo sapiens | |
0.1 | - |
ATP | 25°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-phenylalanine + tRNAPhe | Homo sapiens | - |
AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + L-phenylalanine + tRNAPhe = AMP + diphosphate + L-phenylalanyl-tRNAPhe | tRNAPhe substrate binding mechanism, base-specific interactions between the 3'-end of the tRNA and the enzymes alpha- and beta-subunit | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.19 | - |
pure enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-phenylalanine + tRNAPhe | - |
Homo sapiens | AMP + diphosphate + L-phenylalanyl-tRNAPhe | - |
? |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
CML33 | - |
Homo sapiens |
FRS | - |
Homo sapiens |
HSPC173 | - |
Homo sapiens |
L-Phenylalanyl-tRNA synthetase | - |
Homo sapiens |
Phenylalanine translase | - |
Homo sapiens |
Phenylalanine--tRNA ligase | - |
Homo sapiens |
Phenylalanine-tRNA synthetase | - |
Homo sapiens |
Phenylalanyl transfer ribonucleic acid synthetase | - |
Homo sapiens |
Phenylalanyl-transfer ribonucleate synthetase | - |
Homo sapiens |
Phenylalanyl-transfer RNA ligase | - |
Homo sapiens |
Phenylalanyl-transfer RNA synthetase | - |
Homo sapiens |
Phenylalanyl-tRNA ligase | - |
Homo sapiens |
Phenylalanyl-tRNA synthetase | - |
Homo sapiens |
PheRS | - |
Homo sapiens |
Synthetase, phenylalanyl-transfer ribonucleate | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0002 | - |
PheOH-AMP | 25°C | Homo sapiens | |
0.00035 | - |
tRNAPhe s4-Up77 | 25°C | Homo sapiens | |
0.0004 | - |
tRNAPhe s4-U77 | 25°C | Homo sapiens | |
0.00064 | - |
tRNAPhe s4-U76 | 25°C | Homo sapiens | |
0.00069 | - |
tRNAPhe Cp75 | 25°C | Homo sapiens | |
0.00071 | - |
tRNAPhe s4-U75 | 25°C | Homo sapiens |