Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[5-[(6-(ethoxycarbonyl)-5-(4-fluorophenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]-2-furyl]benzoic acid | - |
Staphylococcus epidermidis | |
3-[(4-[[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-ylidene]methyl]phenoxy) methyl]benzoic acid | - |
Staphylococcus epidermidis | |
3-[[([[2-(4-chlorophenyl)-4-quinolinyl]carbonyl]amino)carbothioyl]amino]benzoic acid | - |
Staphylococcus epidermidis | |
additional information | screening for SeWRS inhibitors, binding site mapping and virtual screening, modeling, overview, MIC values, and cytotoxic activities of inhibitors, overview | Staphylococcus epidermidis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Staphylococcus epidermidis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | Staphylococcus epidermidis | the enzyme is essential for translation | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus epidermidis | Q8CT69 | strain ATCC 12228; strains ATCC 12228 and ATCC 35984 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | - |
Staphylococcus epidermidis | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | the enzyme is essential for translation | Staphylococcus epidermidis | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tryptophanyl-tRNA synthetase | - |
Staphylococcus epidermidis |
WRS | - |
Staphylococcus epidermidis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Staphylococcus epidermidis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Staphylococcus epidermidis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Staphylococcus epidermidis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0151 | - |
pH 8.0, 25°C, assay method b | Staphylococcus epidermidis | 3-[(4-[[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-ylidene]methyl]phenoxy) methyl]benzoic acid | |
0.0183 | - |
pH 8.0, 25°C, assay method a | Staphylococcus epidermidis | 3-[(4-[[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-ylidene]methyl]phenoxy) methyl]benzoic acid | |
0.0187 | - |
pH 8.0, 25°C, assay method b | Staphylococcus epidermidis | 2-[5-[(6-(ethoxycarbonyl)-5-(4-fluorophenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]-2-furyl]benzoic acid | |
0.0228 | - |
pH 8.0, 25°C, assay method a | Staphylococcus epidermidis | 2-[5-[(6-(ethoxycarbonyl)-5-(4-fluorophenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]-2-furyl]benzoic acid | |
0.0352 | - |
pH 8.0, 25°C, assay method b | Staphylococcus epidermidis | 3-[[([[2-(4-chlorophenyl)-4-quinolinyl]carbonyl]amino)carbothioyl]amino]benzoic acid | |
0.0422 | - |
pH 8.0, 25°C, assay method a | Staphylococcus epidermidis | 3-[[([[2-(4-chlorophenyl)-4-quinolinyl]carbonyl]amino)carbothioyl]amino]benzoic acid |