Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.2 extracted from

  • Wu, Y.; Yu, K.; Xu, B.; Chen, L.; Chen, X.; Mao, J.; Danchin, A.; Shen, X.; Qu, D.; Jiang, H.
    Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase (2007), J. Antimicrob. Chemother., 60, 502-509.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-[5-[(6-(ethoxycarbonyl)-5-(4-fluorophenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]-2-furyl]benzoic acid
-
Staphylococcus epidermidis
3-[(4-[[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-ylidene]methyl]phenoxy) methyl]benzoic acid
-
Staphylococcus epidermidis
3-[[([[2-(4-chlorophenyl)-4-quinolinyl]carbonyl]amino)carbothioyl]amino]benzoic acid
-
Staphylococcus epidermidis
additional information screening for SeWRS inhibitors, binding site mapping and virtual screening, modeling, overview, MIC values, and cytotoxic activities of inhibitors, overview Staphylococcus epidermidis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Staphylococcus epidermidis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-tryptophan + tRNATrp Staphylococcus epidermidis the enzyme is essential for translation AMP + diphosphate + L-tryptophanyl-tRNATrp
-
?

Organism

Organism UniProt Comment Textmining
Staphylococcus epidermidis Q8CT69 strain ATCC 12228; strains ATCC 12228 and ATCC 35984
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-tryptophan + tRNATrp
-
Staphylococcus epidermidis AMP + diphosphate + L-tryptophanyl-tRNATrp
-
?
ATP + L-tryptophan + tRNATrp the enzyme is essential for translation Staphylococcus epidermidis AMP + diphosphate + L-tryptophanyl-tRNATrp
-
?

Synonyms

Synonyms Comment Organism
Tryptophanyl-tRNA synthetase
-
Staphylococcus epidermidis
WRS
-
Staphylococcus epidermidis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Staphylococcus epidermidis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Staphylococcus epidermidis

Cofactor

Cofactor Comment Organism Structure
ATP
-
Staphylococcus epidermidis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0151
-
pH 8.0, 25°C, assay method b Staphylococcus epidermidis 3-[(4-[[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-ylidene]methyl]phenoxy) methyl]benzoic acid
0.0183
-
pH 8.0, 25°C, assay method a Staphylococcus epidermidis 3-[(4-[[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-ylidene]methyl]phenoxy) methyl]benzoic acid
0.0187
-
pH 8.0, 25°C, assay method b Staphylococcus epidermidis 2-[5-[(6-(ethoxycarbonyl)-5-(4-fluorophenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]-2-furyl]benzoic acid
0.0228
-
pH 8.0, 25°C, assay method a Staphylococcus epidermidis 2-[5-[(6-(ethoxycarbonyl)-5-(4-fluorophenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]-2-furyl]benzoic acid
0.0352
-
pH 8.0, 25°C, assay method b Staphylococcus epidermidis 3-[[([[2-(4-chlorophenyl)-4-quinolinyl]carbonyl]amino)carbothioyl]amino]benzoic acid
0.0422
-
pH 8.0, 25°C, assay method a Staphylococcus epidermidis 3-[[([[2-(4-chlorophenyl)-4-quinolinyl]carbonyl]amino)carbothioyl]amino]benzoic acid