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Literature summary for 6.1.1.18 extracted from

  • Ko, Y.G.; Kim, E.Y.; Kim, T.; Park, H.; Park, H.S.; Choi, E.J.; Kim, S.
    Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1 (2001), J. Biol. Chem., 276, 6030-6036.
    View publication on PubMed
Search for more literature for 6.1.1.18

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamine + tRNAGln Homo sapiens
-
 AMP + diphosphate + L-glutaminyl-tRNAGln
-
 ?
additional information Homo sapiens the enzyme interacts with the apoptosis signal-regulating kinase ASK1, which involves the active sites of the enzymes and inhibits AKS1, the association is mediated and enhanced by glutamine, it is inhibited by Fas ligation, the enzyme inhibits ASK1-induced apoptosis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 purified recombinant His-tagged enzyme expressed in Escherichia coli
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamine + tRNAGln
-
 Homo sapiens AMP + diphosphate + L-glutaminyl-tRNAGln
-
 ?
additional information the enzyme interacts with the apoptosis signal-regulating kinase ASK1, which involves the active sites of the enzymes and inhibits AKS1, the association is mediated and enhanced by glutamine, it is inhibited by Fas ligation, the enzyme inhibits ASK1-induced apoptosis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Glutaminyl-tRNA synthetase
-
 Homo sapiens
QRS
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens