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Literature summary for 6.1.1.17 extracted from

  • Mizrachi Nebenzahl, Y.; Bernstein, A.; Portnoi, M.; Shagan, M.; Rom, S.; Porgador, A.; Dagan, R.
    Streptococcus pneumoniae surface-exposed glutamyl tRNA synthetase, a putative adhesin, is able to induce a partially protective immune response in mice (2007), J. Infect. Dis., 196, 945-953.
    View publication on PubMed
Search for more literature for 6.1.1.17

Cloned(Commentary)

Cloned (Comment) Organism
gene gltX, DNA and amino acid sequence determination and analysis, expression in Escherichia coli Streptococcus pneumoniae

Inhibitors

Inhibitors Comment Organism Structure
additional information rGtS and anti-rGtS antiserum significantly inhibits the adhesion of 3 pairs of encapsulated and unencapsulated strains of Streptococcus pneumoniae to human epithelial A549 cells Streptococcus pneumoniae

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
 Streptococcus pneumoniae 9986
-
cell wall the enzyme is surface-exposed Streptococcus pneumoniae 5618
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Streptococcus pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
 x * 58000, recombinant enzyme, SDS-PAGE Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + tRNAGlu Streptococcus pneumoniae
-
 AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
additional information Streptococcus pneumoniae GtS is an age-dependent Streptococcus pneumoniae antigen and is a surface-located adhesin that is capable of inducing a partially protective immune response against Streptococcus pneumoniae in mice, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus pneumoniae
-
 several strains and cultivars, overview, gene gltX
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + tRNAGlu
-
 Streptococcus pneumoniae AMP + diphosphate + L-glutamyl-tRNAGlu
-
 ?
additional information GtS is an age-dependent Streptococcus pneumoniae antigen and is a surface-located adhesin that is capable of inducing a partially protective immune response against Streptococcus pneumoniae in mice, overview Streptococcus pneumoniae ?
-
 ?

Subunits

Subunits Comment Organism
? x * 58000, recombinant enzyme, SDS-PAGE Streptococcus pneumoniae

Synonyms

Synonyms Comment Organism
GtS
-
 Streptococcus pneumoniae
surface-exposed glutamyl tRNA synthetase
-
 Streptococcus pneumoniae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Streptococcus pneumoniae