Literature summary for 6.1.1.17 extracted from

Rinehart, J.; Horn, E.K.; Wei, D.; Soll, D.; Schneider, A.
Non-canonical eukaryotic glutaminyl- and glutamyl-tRNA synthetases form mitochondrial aminoacyl-tRNA in Trypanosoma brucei (2004), J. Biol. Chem., 279, 1161-1166.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-glutamate + tRNAGlu	Trypanosoma brucei	eukaryotic-type discriminating glutamyl-tRNA synthetase, inability to utilize Escherichia coli tRNA as substrate. The enzyme is essential for growth of insect stage Trypanosoma brucei and is responsible for essentially all of the glutamyl-tRNA synthetase activity in cytosol and in mitochondria	AMP + diphosphate + L-glutamyl-tRNAGlu	-	?

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamate + tRNAGlu	eukaryotic-type discriminating glutamyl-tRNA synthetase, inability to utilize Escherichia coli tRNA as substrate. The enzyme is essential for growth of insect stage Trypanosoma brucei and is responsible for essentially all of the glutamyl-tRNA synthetase activity in cytosol and in mitochondria	Trypanosoma brucei	AMP + diphosphate + L-glutamyl-tRNAGlu	-	?
ATP + L-glutamate + tRNAGlu	eukaryotic-type discriminating glutamyl-tRNA synthetase, inability to utilize Escherichia coli tRNA as substrate	Trypanosoma brucei	AMP + diphosphate + L-glutamyl-tRNAGlu	-	?

Synonyms

Synonyms	Comment	Organism
GluRS	-	Trypanosoma brucei
Glutamyl-tRNA synthetase	-	Trypanosoma brucei

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Release 2023.1 (January 2023)