Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.15 extracted from

  • Young, S.K.; Baird, T.D.; Wek, R.C.
    Translation regulation of the glutamyl-prolyl-tRNA synthetase gene EPRS through bypass of upstream open reading frames with noncanonical initiation codons (2016), J. Biol. Chem., 291, 10824-10835 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.15

Cloned(Commentary)

Cloned (Comment) Organism
gene EPRS, quantitative PCR-based expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information transfection of MEF cells with the PTK-EPRS-Luc reporter followed by either halofuginone treatment or no treatment Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Mus musculus
-
MEF cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
EPRS
-
 Mus musculus
glutamyl-prolyl-tRNA synthetase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus UUG1 and CUG2 are overall repressing elements in EPRS translation control down
Mus musculus the translation of the glutamyl-prolyl-tRNA synthetase gene EPRS is enhanced in response to phosphorylated eukaryotic initiation factor 2, eIF2alpha-P, mechanism of translation control involving increased translation initiation stringency during stress-induced eIF2alpha-P, facilitated ribosome bypass of upstream ORFs, allowing for increased translation of the EPRS coding region, overview. Both halofuginone and thapsigargin treatment result in a 2.5fold induction of EPRS expression up

General Information

General Information Comment Organism
physiological function mechanism of translation control of enzyme EPRS involving increased translation initiation stringency during stress-induced eIF2alpha-P, facilitated ribosome bypass of upstream ORFs, allowing for increased translation of the EPRS coding region. The 5'-leader of the EPRS mRNA directs preferential translation. Although a portion of the ribosomes that translate uORF2 can reinitiate downstream, scanning ribosomes also bypass uORF2 because of its noncanonical UUG1 initiation codon and initiate translation at the downstream coding sequence. UUG1 and CUG2 are overall repressing elements in EPRS translation control. Model for EPRS translation control, overview Mus musculus