Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21-(DE3)R3 Rosetta cells | Plasmodium falciparum |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method, using 10% (w/v) PEG-800, 20% (v/v) ethylene glycol, 0.1 M MES/imidazole, pH 6.5, and 0.03 M each sodium fluoride, sodium bromide, and sodium iodide | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide | - |
Plasmodium falciparum | |
3-[4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-1H-pyrazol-3-yl]propanamide | - |
Plasmodium falciparum | |
4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-amine | - |
Plasmodium falciparum | |
4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-1H-pyrazole-3-carboxamide | - |
Plasmodium falciparum | |
febrifugine | - |
Plasmodium falciparum | |
glyburide | - |
Plasmodium falciparum | |
halofuginone | - |
Plasmodium falciparum | |
N-(2,4-difluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(3-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[1-methyl-3-(trifluoromethyl)-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-(2-hydroxyethyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-3-(2-hydroxyethyl)-1-methyl-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-[2-(2-hydroxyethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-[2-(hydroxymethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-(4-fluorophenyl)-N'-[4-[3-(2-hydroxyethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | - |
Plasmodium falciparum | |
N-([3-[5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]phenyl]methyl)methanesulfonamide | - |
Plasmodium falciparum | |
N-Boc-halofuginone | less than 20% inhibition at 1 mM | Plasmodium falciparum | |
N-[3-(2-cyanoethyl)-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | - |
Plasmodium falciparum | |
N-[3-(cyanomethyl)-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | - |
Plasmodium falciparum | |
N-[3-cyano-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | - |
Plasmodium falciparum | |
N-[3-[2-(dimethylamino)ethyl]-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | - |
Plasmodium falciparum | |
N-[4-(3,4-difluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | - |
Plasmodium falciparum | |
N-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-methoxyphenyl)urea | - |
Plasmodium falciparum | |
N-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-[2-(morpholin-4-yl)pyridin-4-yl]urea | - |
Plasmodium falciparum | |
N-[4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | - |
Plasmodium falciparum | |
TCMDC-124506 | competitive inhibitor | Plasmodium falciparum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-proline + tRNAPro | Plasmodium falciparum | - |
AMP + diphosphate + L-prolyl-tRNAPro | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8I5R7 | - |
- |
Purification (Comment) | Organism |
---|---|
His Trap column chromatography and Superdex 75 gel filtration | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-proline + tRNAPro | - |
Plasmodium falciparum | AMP + diphosphate + L-prolyl-tRNAPro | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Prolyl-tRNA synthetase | - |
Plasmodium falciparum |
ProRS | - |
Plasmodium falciparum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0025 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-(2,4-difluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.003 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-[2-(morpholin-4-yl)ethyl]-1H-pyrazol-5-yl]urea | |
0.004 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-[3-[2-(dimethylamino)ethyl]-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | |
0.005 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.005 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-[3-cyano-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | |
0.005 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | TCMDC-124506 | |
0.006 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-[3-(cyanomethyl)-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | |
0.008 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-(3-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.008 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | 3-[4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-1H-pyrazol-3-yl]propanamide | |
0.009 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-[3-(2-cyanoethyl)-4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | |
0.013 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-[3-(2-hydroxyethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.014 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | 4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-1H-pyrazole-3-carboxamide | |
0.018 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-3-(2-hydroxyethyl)-1-methyl-1H-pyrazol-5-yl]urea | |
0.02 | - |
at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-[2-(hydroxymethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | 4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-amine | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-(2-hydroxyethyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-(4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-[4-(3,4-difluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-methoxyphenyl)urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-[4-(4-fluorophenyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-[2-(morpholin-4-yl)pyridin-4-yl]urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-[4-bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-N'-(4-fluorophenyl)urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | 2-[4-(4-fluorophenyl)-5-[[(4-fluorophenyl)carbamoyl]amino]-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetamide | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[4-[2-(2-hydroxyethyl)phenyl]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]urea | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-([3-[5-[[(4-fluorophenyl)carbamoyl]amino]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]phenyl]methyl)methanesulfonamide | |
0.05 | - |
IC50 above 0.05 mM, at pH 7.0 and 37°C | Plasmodium falciparum | N-(4-fluorophenyl)-N'-[1-methyl-3-(trifluoromethyl)-4-[3-(trifluoromethyl)phenyl]-1H-pyrazol-5-yl]urea |