Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.1.1.15 extracted from

  • An, S.; Barany, G.; Musier-Forsyth, K.
    Evolution of acceptor stem tRNA recognition by class II prolyl-tRNA synthetase (2008), Nucleic Acids Res., 36, 2514-2521.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.15

Protein Variants

Protein Variants Comment Organism
A57G site-directed mutagenesis, the A57G mutation introduces a BstBI restriction site within the gene, but has no effect on catalytic activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-proline + tRNAPro Homo sapiens
-
 AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-proline + tRNAPro
-
 Homo sapiens AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
ATP + L-proline + tRNAPro semi-synthetic human tRNAPro prepared by annealing a 5'-57-mer fragment to a 3'-16-mer. The 5'-57-mer is prepared by in vitro transcription Homo sapiens AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
additional information substrate specificity, reducing effects of diverse different phosphorothioate substitutions in the 3'-strand of human tRNAPro on aminoacylation efficiency, mechanism, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
class II prolyl-tRNA synthetase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens