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Literature summary for 6.1.1.15 extracted from

  • Yaremchuk, A.; Cusack, S.; Tukalo, M.
    Crystal structure of a eukaryote/archaeon-like protyl-tRNA synthetase and its complex with tRNAPro(CGG) (2000), EMBO J., 19, 4745-4758.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.15

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray diffraction structure determination at 2.43-2.85 A of crystals formed by the free enzyme or the enzyme complexed with tRNAPro Thermus thermophilus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ enzyme contains a unique additional zinc-binding domain Thermus thermophilus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-proline + tRNAPro Thermus thermophilus
-
 AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Organism

Organism UniProt Comment Textmining
Thermus thermophilus
-
 class IIa synthetase of the eukaryote/archaeon-like structure type
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-proline + tRNAPro = AMP + diphosphate + L-prolyl-tRNAPro the C-terminal extremity folds back into the active site Thermus thermophilus
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-proline + tRNAPro
-
 Thermus thermophilus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?
ATP + L-proline + tRNAPro initial docking state of the tRNAPro in which the anticodon stem-loop is engaged, particularly via the tRNAPro-specific bases G35 and G36, but the 3'-end does not enter the active site Thermus thermophilus AMP + diphosphate + L-prolyl-tRNAPro
-
 ?

Synonyms

Synonyms Comment Organism
Global RNA synthesis factor
-
 Thermus thermophilus
Pro-tRNA synthetase
-
 Thermus thermophilus
Proline translase
-
 Thermus thermophilus
Proline--tRNA ligase
-
 Thermus thermophilus
Prolyl RNA synthetase
-
 Thermus thermophilus
Prolyl-transfer ribonucleate synthetase
-
 Thermus thermophilus
Prolyl-transfer ribonucleic acid synthetase
-
 Thermus thermophilus
Prolyl-transfer RNA synthetase
-
 Thermus thermophilus
Prolyl-tRNA synthetase
-
 Thermus thermophilus
ProRS
-
 Thermus thermophilus
ProRSTT
-
 Thermus thermophilus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Thermus thermophilus