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Literature summary for 6.1.1.14 extracted from

  • Andreev, D.E.; Hirnet, J.; Terenin, I.M.; Dmitriev, S.E.; Niepmann, M.; Shatsky, I.N.
    Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation (2012), Nucleic Acids Res., 40, 5602-5614.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta (DE3) cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycine + tRNAGly Homo sapiens
-
AMP + diphosphate + glycyl-tRNAGly
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose column chromatography, and gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycine + tRNAGly
-
Homo sapiens AMP + diphosphate + glycyl-tRNAGly
-
?

Synonyms

Synonyms Comment Organism
GARS
-
Homo sapiens
Glycyl-tRNA synthetase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function glycyl-tRNA synthetase specifically binds to the poliovirus internal ribosome entry site to activate translation initiation Homo sapiens