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Literature summary for 6.1.1.12 extracted from

  • Kim, K.R.; Park, S.H.; Kim, H.S.; Rhee, K.H.; Kim, B.G.; Kim, D.G.; Park, M.S.; Kim, H.J.; Kim, S.; Han, B.W.
    Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex (2013), Proteins, 81, 1840-1846.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli Rosetta2(DE3)pLysS cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-aspartate + tRNAAsp Homo sapiens
-
AMP + diphosphate + L-aspartyl-tRNAAsp
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P14868
-
-

Purification (Commentary)

Purification (Comment) Organism
HiTrap chelating HP column chromatography, HiTrap Q column chromatography, and Superdex 200 gel filtration Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate + tRNAAsp
-
Homo sapiens AMP + diphosphate + L-aspartyl-tRNAAsp
-
?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
Aspartyl-tRNA synthetase
-
Homo sapiens
DRS
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens