Literature summary for 6.1.1.12 extracted from

Messmer, M.; Blais, S.P.; Balg, C.; Chenevert, R.; Grenier, L.; Laguee, P.; Sauter, C.; Sissler, M.; Giege, R.; Lapointe, J.; Florentz, C.
Peculiar inhibition of human mitochondrial aspartyl-tRNA synthetase by adenylate analogs (2009), Biochimie, 91, 596-603.

Search for more literature for 6.1.1.12

Application

Application	Comment	Organism
medicine	the adaption of pathogens to antibiotics calls for new target macromolecules and new types of inhibitors	Escherichia coli
medicine	the adaption of pathogens to antibiotics calls for new target macromolecules and new types of inhibitors	Homo sapiens
medicine	the adaption of pathogens to antibiotics calls for new target macromolecules and new types of inhibitors	Bos taurus
medicine	the adaption of pathogens to antibiotics calls for new target macromolecules and new types of inhibitors	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	ASP-AMS	Bos taurus
5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	ASP-AMS	Escherichia coli
5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	ASP-AMS	Homo sapiens
5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	ASP-AMS	Pseudomonas aeruginosa
L-aspartol-adenylate	aspartol-AMP	Bos taurus
L-aspartol-adenylate	aspartol-AMP	Escherichia coli
L-aspartol-adenylate	aspartol-AMP	Homo sapiens
L-aspartol-adenylate	aspartol-AMP	Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0015	-	L-aspartate	-	Homo sapiens
0.024	-	L-aspartate	-	Homo sapiens
0.037	-	L-aspartate	-	Bos taurus
0.09	-	L-aspartate	-	Escherichia coli
0.1	-	L-aspartate	-	Pseudomonas aeruginosa

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Homo sapiens	5737	-
cytoplasm	-	Bos taurus	5737	-
mitochondrion	-	Homo sapiens	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-aspartate + tRNAAsp	Escherichia coli	-	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?
ATP + L-aspartate + tRNAAsp	Homo sapiens	-	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?
ATP + L-aspartate + tRNAAsp	Bos taurus	-	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?
ATP + L-aspartate + tRNAAsp	Pseudomonas aeruginosa	-	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Escherichia coli	-	-	-
Homo sapiens	-	-	-
Pseudomonas aeruginosa	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-aspartate + tRNAAsp	-	Escherichia coli	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?
ATP + L-aspartate + tRNAAsp	-	Homo sapiens	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?
ATP + L-aspartate + tRNAAsp	-	Bos taurus	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?
ATP + L-aspartate + tRNAAsp	-	Pseudomonas aeruginosa	AMP + diphosphate + L-aspartyl-tRNAAsp	-	?

Synonyms

Synonyms	Comment	Organism
Aspartyl-tRNA synthetase	-	Escherichia coli
Aspartyl-tRNA synthetase	-	Homo sapiens
Aspartyl-tRNA synthetase	-	Bos taurus
Aspartyl-tRNA synthetase	-	Pseudomonas aeruginosa
Bt cyt-AspRS	-	Bos taurus
cytoplasmic aspartyl-tRNA synthetase	-	Homo sapiens
cytoplasmic aspartyl-tRNA synthetase	-	Bos taurus
Ec AspRS	-	Escherichia coli
HS cyt-AspRS	-	Homo sapiens
Hs mt-AspRS	-	Homo sapiens
mitochondrial aspartyl-tRNA synthetase	-	Homo sapiens
Pa AspRS	-	Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	aspartylation and inhibition assay	Escherichia coli
37	-	aspartylation and inhibition assay	Homo sapiens
37	-	aspartylation and inhibition assay	Bos taurus
37	-	aspartylation and inhibition assay	Pseudomonas aeruginosa

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	aspartylation and inhibition assay	Escherichia coli
7.5	-	aspartylation and inhibition assay	Homo sapiens
7.5	-	aspartylation and inhibition assay	Bos taurus
7.5	-	aspartylation and inhibition assay	Pseudomonas aeruginosa

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Escherichia coli
ATP	-	Homo sapiens
ATP	-	Bos taurus
ATP	-	Pseudomonas aeruginosa

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000098	-	5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	-	Homo sapiens
0.000015	-	5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	-	Escherichia coli
0.00028	-	5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	-	Bos taurus
0.00039	-	5'-O-[N-(L-aspartyl)sulfamoyl]adenosine	-	Homo sapiens
0.0046	-	L-aspartol-adenylate	-	Homo sapiens
0.01	-	L-aspartol-adenylate	-	Homo sapiens
0.027	-	L-aspartol-adenylate	-	Bos taurus
0.041	-	L-aspartol-adenylate	-	Pseudomonas aeruginosa
0.045	-	L-aspartol-adenylate	-	Escherichia coli

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Release 2023.1 (January 2023)