Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, sequence comparisons, RT-PCR expression analysis, phylogenetic analysis and tree | Bombyx mori |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-serine + tRNASer | Bombyx mori | - |
AMP + diphosphate + L-seryl-tRNASer | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bombyx mori | - |
variety Jingsong x Haoyue | - |
Bombyx mori | A0A1Q1NKM3 | var. Jingsong x Haoyue | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | tissue expression analysis of enzyme TyrRS, the transcription level of TyrRS is significantly higher in silk gland than in other tissues | Bombyx mori | - |
silk gland | - |
Bombyx mori | - |
silk gland | transcription levels are much higher in middle and posterior silk gland than in anterior silk gland | Bombyx mori | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-serine + tRNASer | - |
Bombyx mori | AMP + diphosphate + L-seryl-tRNASer | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SerRS | - |
Bombyx mori |
Seryl-tRNA synthetase | - |
Bombyx mori |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bombyx mori |
Organism | Comment | Expression |
---|---|---|
Bombyx mori | treatment of silkworms with phoxim, an inhibitor of silk protein synthesis, but not TiO2 NP, an enhancer of silk protein synthesis, significantly reduce the transcription levels of aminoacyl-tRNA synthetases and content of free amino acids in posterior silk gland, therefore affecting silk protein synthesis, which may be the mechanism of phoxim-silking disorders. Low concentration of TiO2 NPs shows no effect on the transcription of aminoacyl-tRNA synthetases and content of free amino acids, suggesting that TiO2 NPs promotes silk protein synthesis possibly by increasing the activity of fibroin synthase in silkworm | down |
General Information | Comment | Organism |
---|---|---|
evolution | SerRS belongs to the class II aminoacyl-tRNA synthetases (aaRSs), evolutionary analysis of SerRS and TyrRS, overview | Bombyx mori |
physiological function | aminoacyl-tRNA synthetases (aaRSs) for glycine, alanine, serine and tyrosine play important roles in fibroin synthesis | Bombyx mori |