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Literature summary for 6.1.1.10 extracted from

  • Eissa, A.G.; Blaxland, J.A.; Williams, R.O.; Metwally, K.A.; El-Adl, S.M.; Lashine, E.L.-S.M.; Baillie, L.W.; Simons, C.
    Targeting methionyl tRNA synthetase design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives (2016), J. Enzyme Inhib. Med. Chem., 31, 1694-1697 .
    View publication on PubMed
Search for more literature for 6.1.1.10

Inhibitors

Inhibitors Comment Organism Structure
(E)-N-[3-(1H-benzimidazol-1-yl)propyl]-1-(3,5-dimethoxyphenyl)methanimine
-
 Clostridioides difficile
(E)-N-[3-(1H-benzimidazol-1-yl)propyl]-1-(4-bromophenyl)methanimine
-
 Clostridioides difficile
(E)-N-[3-(1H-benzimidazol-1-yl)propyl]-1-(4-chlorophenyl)methanimine
-
 Clostridioides difficile
(E)-N-[3-(1H-benzimidazol-1-yl)propyl]-1-(4-methoxyphenyl)methanimine
-
 Clostridioides difficile
(E)-N-[3-(1H-benzimidazol-1-yl)propyl]-1-phenylmethanimine
-
 Clostridioides difficile
3-(1H-benzimidazol-1-yl)-N-benzylpropan-1-amine
-
 Clostridioides difficile
3-(1H-benzimidazol-1-yl)-N-[(3,5-dimethoxyphenyl)methyl]propan-1-amine
-
 Clostridioides difficile
3-(1H-benzimidazol-1-yl)-N-[(4-bromophenyl)methyl]propan-1-amine
-
 Clostridioides difficile
3-(1H-benzimidazol-1-yl)-N-[(4-chlorophenyl)methyl]propan-1-amine
-
 Clostridioides difficile
3-(1H-benzimidazol-1-yl)-N-[(4-methoxyphenyl)methyl]propan-1-amine
-
 Clostridioides difficile
9-(3-[(E)-[(3,5-dimethoxyphenyl)methylidene]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-(3-[(E)-[(4-bromophenyl)methylidene]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-(3-[(E)-[(4-chlorophenyl)methylidene]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-(3-[(E)-[(4-methoxyphenyl)methylidene]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-(3-[[(3,5-dimethoxyphenyl)methyl]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-(3-[[(4-bromophenyl)methyl]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-(3-[[(4-chlorophenyl)methyl]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-(3-[[(4-methoxyphenyl)methyl]amino]propyl)-9H-purin-6-amine
-
 Clostridioides difficile
9-[3-(benzylamino)propyl]-9H-purin-6-amine
-
 Clostridioides difficile
9-[3-[(E)-benzylideneamino]propyl]-9H-purin-6-amine
-
 Clostridioides difficile
REP3123
-
 Clostridioides difficile

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + tRNAMet Clostridioides difficile
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?
ATP + L-methionine + tRNAMet Clostridioides difficile 1813
-
 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridioides difficile
-
-
-
Clostridioides difficile 1813
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + tRNAMet
-
 Clostridioides difficile AMP + diphosphate + L-methionyl-tRNAMet
-
 ?
ATP + L-methionine + tRNAMet
-
 Clostridioides difficile 1813 AMP + diphosphate + L-methionyl-tRNAMet
-
 ?

Synonyms

Synonyms Comment Organism
Methionyl tRNA synthetase
-
 Clostridioides difficile
MetRS
-
 Clostridioides difficile

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Clostridioides difficile