Application | Comment | Organism |
---|---|---|
drug development | TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections | Staphylococcus aureus |
drug development | TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections | Escherichia coli |
drug development | TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections | Pseudomonas aeruginosa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acacetin | strong inhibition | Escherichia coli | |
acacetin | strong inhibition | Pseudomonas aeruginosa | |
acacetin | strong inhibition | Staphylococcus aureus | |
chrysin | strong inhibition | Escherichia coli | |
chrysin | strong inhibition | Pseudomonas aeruginosa | |
chrysin | strong inhibition | Staphylococcus aureus | |
epigallocatechin gallate | strong inhibition | Escherichia coli | |
kaempferide | strong inhibition | Escherichia coli | |
additional information | natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring | Escherichia coli | |
additional information | natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring | Pseudomonas aeruginosa | |
additional information | natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring | Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0AGJ9 | - |
- |
Pseudomonas aeruginosa | Q9HWP3 | - |
- |
Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 | Q9HWP3 | - |
- |
Staphylococcus aureus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
Tyrosyl-tRNA synthetase | - |
Staphylococcus aureus |
Tyrosyl-tRNA synthetase | - |
Escherichia coli |
Tyrosyl-tRNA synthetase | - |
Pseudomonas aeruginosa |
TyrRS | - |
Staphylococcus aureus |
TyrRS | - |
Escherichia coli |
TyrRS | - |
Pseudomonas aeruginosa |