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Literature summary for 6.1.1.1 extracted from

  • Skupinska, M.; Stepniak, P.; Letowska, I.; Rychlewski, L.; Barciszewska, M.; Barciszewski, J.; Giel-Pietraszuk, M.
    Natural compounds as inhibitors of tyrosyl-tRNA synthetase (2017), Microb. Drug Resist., 23, 308-320 .
    View publication on PubMed

Application

Application Comment Organism
drug development TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections Staphylococcus aureus
drug development TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections Escherichia coli
drug development TyrRS enzymes are candidates for therapeutic targets in the prevention and therapy of microbial infections Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
acacetin strong inhibition Escherichia coli
acacetin strong inhibition Pseudomonas aeruginosa
acacetin strong inhibition Staphylococcus aureus
chrysin strong inhibition Escherichia coli
chrysin strong inhibition Pseudomonas aeruginosa
chrysin strong inhibition Staphylococcus aureus
epigallocatechin gallate strong inhibition Escherichia coli
kaempferide strong inhibition Escherichia coli
additional information natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring Escherichia coli
additional information natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring Pseudomonas aeruginosa
additional information natural compounds as inhibitors of tyrosyl-tRNA synthetase, effects of various polyphenols, alkaloids, and terpenes-secondary metabolites produced by higher plants, overview. Most of them act as competitive inhibitors. Structure-activity relationship shows that the most potent flavonoid inhibitors contain hydroxyl group at position 5 and 7 of A ring and a -OCH3 group at position 4' of B ring Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AGJ9
-
-
Pseudomonas aeruginosa Q9HWP3
-
-
Pseudomonas aeruginosa ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1 Q9HWP3
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-
Staphylococcus aureus
-
-
-

Synonyms

Synonyms Comment Organism
Tyrosyl-tRNA synthetase
-
Staphylococcus aureus
Tyrosyl-tRNA synthetase
-
Escherichia coli
Tyrosyl-tRNA synthetase
-
Pseudomonas aeruginosa
TyrRS
-
Staphylococcus aureus
TyrRS
-
Escherichia coli
TyrRS
-
Pseudomonas aeruginosa